Publication: Prolonged kallikrein inhibition does not
affect the basal growth and secretory capacity
of rat adrenal cortex, but enhances mineralo- and
glucocorticoid response to ACTH and handling stress
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Date
2000
Authors
Rebuffat, P. ; Neri, G. ; Bahgelioglu, M. ; Malendowicz, L.K. ; Nussdorfer, G.G.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The effects on the pituitary-adrenocortical
functions of the prolonged (7-day) blockade of
endogenous bradykinin (BK) synthesis, obtained by the
administration of the kallikrein inhibitor (K-I)
cyclohexylacetyl-Phe-Arg-Ser-Val-Gln amide, were
investigated in the rat. K-I treatment did not cause
significant changes in the (i) body and adrenal weights;
(ii) basal plasma levels of ACTH, aldosterone and
corticosterone; and (iii) average volume of adrenocortical
cells and their basal secretory capacity.
Conversely, K-I administration induced a significant
magnification of the in vivo mineralo- and glucocorticoid
responses to the intraperitoneal (i.p.) bolus injection of
ACTH. Moreover, K-I-treated rats, but not control ones,
displayed a moderate and short-term adrenal secretory
response to the mild stress evoked by the placebo i.p.
injection. Collectively, these findings rule out the
possibility that endogenous BK plays a relevant role in
the control of adrenocortical function under basal
conditions. However, they suggest that endogenous BK
may be involved in quenching exceedingly high
adrenocortical responses to ACTH and stresses.
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