Publication: von Willebrand factor links primary hemostasis to innate immunity.
Authors
Drakeford, Clive ; Águila Martínez, Sonia ; Roche, Fiona ; Hokamp, Karsten ; Fazavana, Judicael ; Cervantes, Mariana P. ; Curtis, Annie M. ; Hawerkamp, Heike C. ; Dhami, Sukhraj Pal Singh ; Charles-Messance, Hugo ; Hackett, Emer E. ; Chion, Alain ; Ward, Soracha ; Ahmad, Azaz ; Schoen, Ingmar ; Breen, Eamon ; Keane, Joe ; Murphy,Ross ; Preston, Roger J. S. ; O’Sullivan, Jamie M. ; Sheedy, Frederick J. ; Fallon, Padraic ; O’Donnell, James S.
item.page.secondaryauthor
item.page.director
Publisher
Nature Research
publication.page.editor
publication.page.department
DOI
https://doi.org/10.1038/s41467-022-33796-7
item.page.type
info:eu-repo/semantics/article
Description
Abstract
The plasma multimeric glycoprotein von Willebrand factor (VWF) plays a critical role in primary hemostasis by tethering platelets to exposed collagen at sites of vascular injury. Recent studies have identified additional biological roles forVWF, and in particular suggest that VWFmay play an important role in regulating inflammatory responses. However, the molecular mechanisms through which VWF exerts its immuno-modulatory effects remain poorly understood. In this study, we report that VWFbinding to macrophages triggers downstream MAP kinase signaling, NF-κB activation and production of proinflammatory cytokines and chemokines. In addition, VWF binding also drives macrophage M1 polarization and shifts macrophage metabolism towards glycolysis in a p38-dependent manner. Cumulatively, our findings define an important biological role for VWF in modulating macrophage function, and thereby establish a novel link between primary hemostasis and innate immunity.
publication.page.subject
Citation
Drakeford, C., Aguila, S., Roche, F. et al. von Willebrand factor links primary hemostasis to innate immunity. Nat Commun 13, 6320 (2022).
item.page.embargo
Collections
Ir a Estadísticas
Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by/4.0/