Publication: The intracellular origin of the melanosome
in pigment cells. A review of ultrastructural data
Authors
Schraerrneyer, U.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
This paper is a review about the ultrastructural
data dealing with the origin of the melanin
granules in retina1 pigment epithelial cells, in melanocytes,
in the ink gland of cuttle fish, in Kupffer cells of
the liver, in neurona1 tissues, in cultured pigment cells.
The role and structure of lysosomes in melanogenesis
are discussed in a separate chapter. The early steps of
melanogenesis are ultrastructurally very heterogeneous,
even in the same cell types. With respect to this
heterogeneity and the considerably different views on
melanosome origin in the literature, the author
hypothesizes that pigment cells may use protein matrices
originated from different cellular pathways.
1) They may either produce a specific protein matrix
and be converted into melanin in the classical way, or 2)
altematively, a matrix resulting from lysosomal protein
degradation or endocytotic pathways may be used and
converted into melanin, as found in fibroblasts
transfected with the tyrosinase gen or in Kupffer cells.
The very heterogeneous ultrastructure of the
polymerizing melanin may be influenced by the amount
and sterical availability of tyrosine residues in the
protein moieties and the activity of tyrosinase.
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