Publication: The role of mitochondrial fusion and fission in the process of cardiac oxidative stress
Authors
Yu, Fei ; Abdelwahid, Eltyeb ; Xu, Tao ; Hu, Longgang ; Wang, Man ; Li, Yuzhen ; Mogharbel, Bassam Felipe ; Teixeira de Carvalho, Katherine Athayde ; Guarita-Souza, Luiz Cesar ; An, Yi ; Li, Peifng
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-191
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info:eu-repo/semantics/article
Description
Abstract
Summary. Mitochondria are the energy suppliers in the
cell and undergo constant fusion and fission to meet
metabolic demand during the cell life cycle. Well-
balanced mitochondrial dynamics are extremely
important and necessary for cell survival as well as for
tissue homeostasis. Cardiomyocytes contain large
numbers of mitochondria to satisfy the high energy
demand. It has been established that deregulated
processes of mitochondrial dynamics play a major role
in myocardial cell death. Currently, cardiac
mitochondrial cell death pathways attract great attention
in the cell biology and regenerative medicine fields.
Importantly, mitochondrial dynamics are tightly linked
to oxidative stress-induced cardiac damage. This review
summarizes molecular mechanisms of mitochondrial
fusion and fission processes and their potential roles in
myocardial cell death triggered by oxidative stress.
Advances in understanding the effect of both normal and
abnormal mitochondrial dynamics on heart protection
will lead to significant improvement of therapeutic
discoveries
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Citation
Histology and Histopathology Vol. 35, nº6 (2020)
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