Publication:
Ring finger protein 126: a potential biomarker for colorectal cancer

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dc.contributor.authorHuang, Chaoqun
dc.contributor.authorMin, Yao
dc.contributor.authorLiu, Jiuyang
dc.contributor.authorLi, Jing
dc.contributor.authorYang, Xiaojun
dc.date.accessioned2023-01-13T10:33:27Z
dc.date.available2023-01-13T10:33:27Z
dc.date.issued2021
dc.description.abstractBackground. Colorectal cancer (CRC) is the most common cancer of the digestive system. However, effective therapeutic targets against CRC have not been found yet. Further, the relationship between the expression of ring finger protein 126 (RNF126) and CRC is not clear. Material and Methods. The expression level of RNF126 in CRC tissues and cell lines was detected by immunohistochemical staining and western blot. Subsequently, endogenous RNF126 expression was inhibited in a CRC cell line using a short hairpin RNA. Next, the effect of RNF126 on the properties of CRC cells was studied through different experimental methods. Results. We found that the RNF126 protein was mainly localized in the cytoplasm. High RNF126 expression was observed to be an independent risk factor for poor prognosis in CRC patients. In vitro studies showed that RNF126 was able to promote the proliferation, migration, and invasion ability of CRC cells. Conclusion. RNF126 acts as an oncogene during CRC development, and may serve as a novel target for CRC treatment.es
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dc.format.extent8es
dc.identifier.citationHistology and Histopathology Vol. 36, nº5 (2021)
dc.identifier.doihttps://doi.org/10.14670/HH-18-328
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/127304
dc.languageenges
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectColorectal canceres
dc.subjectRNF126es
dc.subjectPrognosises
dc.subjectOncogenees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleRing finger protein 126: a potential biomarker for colorectal canceres
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.36, nº5 (2021)