Publication: Matrix metalloproteinases in squamous cell carcinoma
Authors
Johansson, N. ; Kahari, V.M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Controlled degradation of extracellular
matrix (ECM) is essential in many physiological
situations including developmental tissue remodeling,
angiogenesis, tissue repair, and normal turnover of
ECM. In addition, degradation of matrix components is
an important feature of tumor growth, invasion,
metastasis, and tumor-induced angiogenesis. Matrix
metallo-proteinases (MMPs) are a family of zincdependent
neutral endopeptidases, which are collectively
capable of degrading essentially all ECM components.
MMPs apparently play an important role in all the above
mentioned aspects of tumor development. In addition,
there is recent evidence that MMP activity is required
for tumor cell survival. At present, several MMP
inhibitors are in clinical trials of malignant tumors of
different histogenetic origin. In this review we discuss
the current view on the role of MMPs and their
inhibitors in development and invasion of squamous cell
carcinomas, as a basis for prognostication and
therapeutic intervention in these tumors.
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