Publication: Transcriptional regulation of the bcl-x gene encoding the anti-apoptotic Bcl-xL protein by Ets, Rel/NFKB STAT and
AP1 transcription factor families
Authors
Sevilla, L. ; Zaldumbide, A. ; Pognonec, P. ; Boulukos, K.E.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Transcription factors play an essential role in
determining the fate of a cell by affecting the expression
of target genes involved in proliferation, in
differentiation and in programmed cell death. Under
certain conditions, some of these factors are capable of
deregulating expression of genes involved in the cell
cycle andlor in programmed cell death resulting in
uncontrolled proliferation of the cell. The focus of this
review is on the transcriptional regulation of the bcl-x
gene encoding the anti-apoptotic Bcl-xL protein. Since
1999, severa1 papers have implicated members of the
Ets, R~~/NFKSBT, N and AP-1 families as transcription
factors regulating bcl-x expression. A specific emphasis
of these different transcription factor families on bcl-x
regulation in hematopoietic cells is discussed
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Citation
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