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Fluorescence in situ hybridization for ambiguous melanocytic tumors

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dc.contributor.authorGammon, Bryan
dc.contributor.authorGerami, Pedram
dc.date.accessioned2017-11-09T16:54:49Z
dc.date.available2017-11-09T16:54:49Z
dc.date.issued2012
dc.description.abstractThe large majority of melanocytic lesions can be reliably classified as either benign or malignant based upon morphology alone, but a minority of lesions remains difficult to classify by traditional histologic methods. Recently, a panel of fluorescence in situ hybridization (FISH) probes targeting loci on chromosomes 6 and 11 has emerged as a powerful tool to discriminate melanoma from nevi. This has been validated in numerous difficult diagnostic scenarios. In addition, this same FISH panel has been shown to provide independent prognostic information in traditional melanomas. There is accumulating evidence that FISH targeting these loci as well as several other key chromosomal loci such as 9p21 and 8q24 can provide valuable prognostic information in histologically ambiguous melanocytic tumors. However, since the vast majority of atypical spitz tumors have an indolent course, larger studies including adequate numbers of cases with adverse events is necessary to provide sufficient proof of its role in clinically relevant cases. In this review, we discuss the current literature and studies to date on this topic.es
dc.formatapplication/pdfes
dc.format.extent4es
dc.identifier.citationHistology and histopathology, Vol. 27, n.º 12 (2012)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/54477
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectFluorescence in situ hybridizationes
dc.subjectMelanomaes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleFluorescence in situ hybridization for ambiguous melanocytic tumorses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.27, nº12 (2012)