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An enzyme that inactivates the inflammatory mediator leukotriene B4 restricts mycobacterial infection

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dc.contributor.authorDavid M. Tobin
dc.contributor.authorFrancisco J. Roca
dc.contributor.authorRay, John P.
dc.contributor.authorKo, Dennis C.
dc.contributor.authorRamakrishnan, Lalita
dc.contributor.authorRoca Soler, Francisco José
dc.contributor.departmentBioquímica y Biología Molecular B e Inmunología
dc.date.accessioned2026-02-25T15:56:50Z
dc.date.available2026-02-25T15:56:50Z
dc.date.copyright© The Authors 2013
dc.date.issued2013-07-11
dc.description.abstractWhile tuberculosis susceptibility has historically been ascribed to failed inflammation, it is now known that an excess of leukotriene A4 hydrolase (LTA4H), which catalyzes the final step in leukotriene B4 (LTB4) synthesis, produces a hyperinflammatory state and tuberculosis susceptibility. Here we show that the LTB4-inactivating enzyme leukotriene B4 dehydrogenase/prostaglandin reductase 1 (LTB4DH/PTGR1) restricts inflammation and independently confers resistance to tuberculous infection. LTB4DH overexpression counters the susceptibility resulting from LTA4H excess while ltb4dh-deficient animals can be rescued pharmacologically by LTB4 receptor antagonists. These data place LTB4DH as a key modulator of TB susceptibility and suggest new tuberculosis therapeutic strategies.
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dc.identifier.citationTobin DM, Roca FJ, Ray JP, Ko DC, Ramakrishnan L (2013) An Enzyme That Inactivates the Inflammatory Mediator Leukotriene B4 Restricts Mycobacterial Infection. PLoS ONE 8(7): e67828. doi:10.1371/journal.pone.0067828
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0067828
dc.identifier.eissn1932-6203
dc.identifier.urihttp://hdl.handle.net/10201/213501
dc.languageeng
dc.publisherPublic Library of Science
dc.relationFunded by grants from the NIH (L.R.), a Mallinckrodt Scholar Award (D.M.T.), a postdoctoral fellowship from the educational ministry of Spain (F.J.R.), the NWRCE for Biodefense and Emerging Infectious Diseases (L.R. and D.C.K.). D.M.T. is a recipient of the NIH Director’s New Innovator Award and L.R. is a recipient of the NIH Director’s Pioneer Award.
dc.relation.publisherversionhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0067828
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.odsObjetivo 3: Salud
dc.titleAn enzyme that inactivates the inflammatory mediator leukotriene B4 restricts mycobacterial infection
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
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relation.isAuthorOfPublication7f46a88a-1ff4-4f80-948e-7d636b80e75d
relation.isAuthorOfPublication.latestForDiscovery7f46a88a-1ff4-4f80-948e-7d636b80e75d
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