Publication: Comparative stereological study on zonation and
cellular composition of adrenal glands of normal and
anencephalic human fetuses. l. Zonation of the gland
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Date
1997
Authors
Bocian-Sobkowska, J. ; Malendowicz, L.K. ; Woíniak, W.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Comparative stereological studies were
performed on zonation of adrenal glands in 10
anencephalic and 11 normal fetuses, aged between 24
and 39 postovulatory weeks.
The development of adrenal fetal zone (FZ) is the
main factor responsible for normal adrenal gland growth
during the intra-uterine life. At the end of fetal '3e riod volume of this zone attains over 8200 mm and
constitutes 69-70% of the total gland volume, while
respective values for zona glomerulosa (ZG), zona
fasciculata (ZF) and medulla IM' are 1665 mm3 (14%) 833 mm3 (7%) and 1071 mm (9%). These data were in
striking contrast with those found in adrenals of
anencephalic fetuses, in which volume of the gland
attained only ca 35% of that in normal fetuses. In the
oldest anencephalic fetus studied (39 weeks) the volume
of the fetal zone was 962 mm3 (ca 8-folds lower than in
normal fetus) comprising only 25% of the total gland
volume. For the remaining zones the values were: ZG -
1501 mm3 (ca 90% of the normal value and 39% of the
total gland volume); ZF - 770 mm3 (ca 92% and 20%
respectively), and M - 539 mm3 (ca 50% and 14%,
respective1 y).
This stereological study provides the first systemic
description of the development of adrenal gland of
anencephalic fetuses in comparison with the normally
developing gland. Moreover, evidence is given that the
growth of adrenal medulla is also retarded in
anencephaly while the growth of the zona glomerulosa
remains rather unaffected.
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