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Insulin-like Growth Factor (IGF) system and gastrointestinal stromal tumours (GIST): present and future

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dc.contributor.authorNannini, Margherita
dc.contributor.authorBiasco, Guido
dc.contributor.authorAstolfi, Annalisa
dc.contributor.authorUrbini, Milena
dc.contributor.authorPantaleo, Maria A.
dc.date.accessioned2019-01-14T15:11:54Z
dc.date.available2019-01-14T15:11:54Z
dc.date.issued2014
dc.description.abstractIn the last decades, the concept that Insulin-like Growth Factor (IGF) axis plays a key role in several steps of tumorigenesis, cancer growth and metastasis has been widely documented. The aberration of the IGF system has been described in many kinds of tumours, providing several lines of evidence in support of IGF receptor type 1 (IGF1R) as molecular target in cancer treatment. Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumor of the gastrointestinal tract, commonly characterized in most cases by KIT and PDGFRA gain mutations. Beyond to the well recognized KIT and PDGFRA gain mutations, in the last years other molecular aberrations have been investigated. Recently, several lines of evidence about the involvement of the IGF system in GIST have been accumulated. The aim of this review is to report all current data about the IGF system involvement in GIST, focusing on the current clinical implication and future perspectives.es
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.citationHistology and Histopathology, vol. 29, nº 2 (2014)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/66339
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectGastrointestinal stromal tumores
dc.subjectInsulin growth factor receptor 1 (IGF1R)es
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes
dc.titleInsulin-like Growth Factor (IGF) system and gastrointestinal stromal tumours (GIST): present and futurees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.29, nº 2 (2014)