Publication: A study of Ki-67, c-erbB2 and cyclin D-1 expression in CIN-I, CIN-III and squamous cell carcinoma of the cervix
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Date
2007
Authors
Carreras, R. ; Alameda, F. ; Mancebo, G. ; García Moreno, Pedro ; Mariñoso, M.L.M. ; Costa, C. ; Fusté, P. ; Baró, Teresa ; Serrano, S.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The histological criteria for cervical
intraepithelial neoplastic lesions and their follow-ups
have been established, but their reproducibility,
specificity and sensibility are not certain.
Immunohistochemical markers provide more
information on each specific case, in order to facilitate
its classification and, eventually, its prognosis. Using
immunohistochemical techniques, this study analyzes
the prognostic value of three markers (Ki-67, c-erbB2
and Cyclin D1) in cases of low grade squamous
intraepithelial neoplasia (CIN-I), high grade squamous
intraepithelial neoplasia (CIN-III), and infiltrating
squamous cell carcinoma (SCC) taken from a group of
cervical samples. In situ hybridization was performed in
order to detect high-risk HPV.
High risk HPV was demonstrated in 82%, 89% and
100% of the LGSIL, HGSIL and SCC cases,
respectively.
C-erbB2 expression was detected in 9%, 33% and
50% of the LSIL, HGSIL and SCC cases, respectively.
The Ki-67 LI was 25%, 68% and 65.5% in the LGSIL,
HGSIL and SCC cases, respectively. Nuclear Cyclin D1
expression was seen in 82%, 11% and 30% of the CINI,
CIN-III and SCC cases, respectively. We observed that
the cytoplasmic cyclin D1 expression increased with the
severity of the lesion instead of the nuclear expression
decreasing with the progression of the pathology.
Nuclear and cytoplasmic Cyclin D1 expression seemed to be related to HPV high risk infection.
We concluded that Cyclin D1, cerbB2 and The Ki-
67 LI expression changed in relation to the severity of
the lesion and that they could be helpful in making a
differential diagnosis.
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