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NFKB and NFKBI polymorphisms in relation to susceptibility of tumour and other diseases

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dc.contributor.authorSun, X-F.
dc.contributor.authorZhang, H.
dc.date.accessioned2012-09-17T17:57:30Z
dc.date.available2012-09-17T17:57:30Z
dc.date.issued2007
dc.description.abstractNuclear factor-kB (NF-kB) is responsible for the expression by regulating many genes for immune response, cell adhesion, differentiation, proliferation, angiogenesis and apoptosis. The function of NF-kB is inhibited by binding to NF-kB inhibitor (IkB), and imbalance of NF-kB and IkB has been associated with development of many diseases, including tumours. In this review, we focus on polymorphisms of the NFKB and NFKBI genes in relation to development of common inflammatory diseases including ulcerative colitis (UC), Crohn’s disease (CD), rheumatoid arthritis, systemic lupus erythematosus, psoriatic arthritis, giant cell arthritis, type 1 diabetes, multiple sclerosis, celiac disease, and Parkinson’s disease, as well as susceptibility of several cancers, such as oral squamous cell carcinoma, colorectal cancer (CRC), hepatocellular carcinoma, breast cancer and myeloma.es
dc.formatapplication/pdfes
dc.format.extent12es
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/28487
dc.languageenges
dc.publisherMurcia: F. Hernándezes
dc.relation.ispartofHistology and histopathology, vol. 22, nº12 (2007)es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectPolymorphismes
dc.subjectTumourses
dc.subject.other616.5 - Piel. Dermatología clínicaes
dc.titleNFKB and NFKBI polymorphisms in relation to susceptibility of tumour and other diseaseses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.22, nº12 (2007)