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Relationship between lung function and exhaled volatile organic compounds in healthy infants

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dc.contributor.authorSola‐Martínez, Rosa A.
dc.contributor.authorSánchez-Solís de Querol, Manuel
dc.contributor.authorLozano Terol, Gema
dc.contributor.authorGallego Jara, Julia
dc.contributor.authorGarcía-Marcos Álvarez, Luis Vicente
dc.contributor.authorCánovas Díaz, Manuel
dc.contributor.authorDiego Puente, Teresa de
dc.contributor.authorNELA Study Group
dc.contributor.departmentCirugía, Pediatría y Obstetricia y Ginecología
dc.contributor.otherFacultad de Medicina
dc.date.accessioned2025-11-11T12:05:04Z
dc.date.available2025-11-11T12:05:04Z
dc.date.copyright© 2022 The Authors
dc.date.issued2022-01-29
dc.description.abstractObjective: The aim of this study is to assess, for the first time, the relationship between the volatilome and lung function in healthy infants, which may be of help for the early detection of certain respiratory diseases. Lung function tests are crucial in chronic respiratory diseases diagnosis. Moreover, volatile organic compounds (VOCs) analysis in exhaled breath is a noninvasive technique that enables the monitorization of oxidative stress, typical of some forms of airway inflammation. Methods: Lung function was studied in 50 healthy infants of 3–8 months of age and the following parameters were obtained: forced vital capacity (FVC), forced ex piratory volume at 0.5 s (FEV0.5), forced expiratory flow at 75% of FVC (FEF75), forced expiratory flow at 25%–75% of FVC (FEF25–75), and FEV0.5/FVC. Lung function was measured according to the raised volume rapid thoracoabdominal compression technique. In addition, a targeted analysis of six endogenous VOCs (acetone, isoprene, decane, undecane, tetradecane, and pentadecane) in the exhaled breath of the children was carried out by means of thermal desorption coupled gas chromatography‐single quadrupole mass spectrometry system. Results: A negatively significant relationship has been observed between levels of acetone, tetradecane, and pentadecane in exhaled breath and several of the lung function parameters. Levels of acetone (feature m/z = 58) were significantly nega tively associated with FVC and FVE0.5, levels of tetradecane (feature m/z = 71) with FEV0.5, and levels of pentadecane (feature m/z = 71) with FEV0.5 and FEF25–75. Conclusion: The findings of this study highlight a significant association between VOCs related to oxidative stress and lung function in healthy infants.
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dc.identifier.citationPediatr Pulmonol. 2022;57(5):1282-1292
dc.identifier.doihttps://doi.org/10.1002/ppul.25849
dc.identifier.eissn1099-0496
dc.identifier.issn8755-6863
dc.identifier.urihttp://hdl.handle.net/10201/172310
dc.languageeng
dc.publisherWiley-Blackwell
dc.relationInstituto de Salud Carlos III,Spanish Ministry of Science, Innovation, and Universities, and FondosFEDER (Grant Numbers CP14/00046, PIE15/00051, PI16/00422, and ARADyAL network RD160006), and Grant RTI2018‑094393‑B‑C21‑M-CIU/AEI/FEDER funded by MCIN/AEI/10.13039/501100011033/by“ERDF A way of making Europe and the Seneca Foundation CARM,20786/PI/18.
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/10.1002/ppul.25849
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.subjectEarly respiratory diseases detection
dc.subjectExhaled breath analysis
dc.subjectInfant lung function
dc.subjectMonitorization of oxidative stress
dc.subjectVolatile organic compounds
dc.subject.odsObjetivo 3: Salud
dc.titleRelationship between lung function and exhaled volatile organic compounds in healthy infants
dc.typeinfo:eu-repo/semantics/article
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