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Gender-related differences in kidney of rats with chronic renal failure

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dc.contributor.authorLemos, Carla C.S.
dc.contributor.authorMandarim-de-Lacerda, Carlos A.
dc.contributor.authorCarvalho, Jorge J.
dc.contributor.authorBregman, Rachel
dc.date.accessioned2019-02-27T10:29:49Z
dc.date.available2019-02-27T10:29:49Z
dc.date.issued2014
dc.description.abstractChronic renal failure is characterized by adaptive mechanisms secondary to the loss of functioning nephrons. Clinical and experimental studies suggest participation of gender-related hormones on renal function and progression of chronic renal failure. We evaluated the effect of castration on renal alterations in male and female Wistar control rats and after 30 days of chronic renal failure (CRF) induced by 5/6 nephrectomy. The CRF male group showed higher proteinuria. Glomerular hypertrophy was similar amogroups. Podocyte morphology showed disorders of foot processes and thickening of the basement membrane in the CRF male group. The CRF female group showed fewer alterations compared to males. Castration changed the profile in CRF male animals and the filtration barrier was preserved. CRF males showed the presence of alfa-smooth muscle actin suggesting an early prefibrotic event in this group. After castration this phenomenon was not observed. Noteworthy, in females, castration exacerbated the presence of alfa-smooth muscle actin. In summary, proteinuria was higher in males and appeared early in the course of CRF, probably contributing to fibrotic events. Data were influenced by gender suggesting that male sex hormones aggravate renal alterations. Histol Histopathol 29, 479-487 (2014)es
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.citationHistology and Histopathology, vol. 29, nº 4, (2014)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/67925
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectAlfa-smooth muscle actines
dc.subjectCastrationes
dc.subjectChronic renal failurees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleGender-related differences in kidney of rats with chronic renal failurees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.29, nº 4 (2014)