Peroxisome morphology in pathology

Ribeiro, Daniela; Castro, Inês; Fahimi, H. Dariush; Schrader, Michael

Publication:
Peroxisome morphology in pathology

dc.contributor.author	Ribeiro, Daniela
dc.contributor.author	Castro, Inês
dc.contributor.author	Fahimi, H. Dariush
dc.contributor.author	Schrader, Michael
dc.date.accessioned	2017-03-13T14:57:36Z
dc.date.available	2017-03-13T14:57:36Z
dc.date.issued	2012
dc.description.abstract	Summary. Peroxisomes are remarkably dynamic and versatile organelles that are essential for human health and development. They respond to physiological changes in the cellular environment by adapting their morphology, number, enzyme content and metabolic functions accordingly. With the discovery of the first key peroxisomal morphology proteins, the investigation of peroxisomal shape, distribution and dynamics has become an exciting new field in cell biology and biomedical sciences because of its relation to organelle functionality and its impact on developmental and physiological processes. In this review, we summarize recent findings on peroxisome biology, dynamics and the modulation of peroxisome morphology, especially in mammals. Furthermore, we discuss the roles of peroxisome dynamics and morphology in cell pathology and present recent examples for alterations in peroxisome morphology under disease conditions. Besides defects in the peroxisomal morphology machinery, we also address peroxisome biogenesis disorders, alterations of peroxisome number during carcinogenesis and liver cirrhosis, and morphological alterations of peroxisomes during viral infection.	es
dc.format	application/pdf	es
dc.format.extent	16	es
dc.identifier.citation	Histology and Histopatholy, Volume 27, number 6 (June), 2012
dc.identifier.issn	1699-5848
dc.identifier.issn	0213-3911
dc.identifier.uri	http://hdl.handle.net/10201/52440
dc.language	eng	es
dc.publisher	F. Hernandez y JuanF. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología.	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.subject	Peroxisomes	es
dc.subject	Organelle dynamics	es
dc.subject.other	CDU::5 - Ciencias puras y naturales::57 - Biología	es
dc.title	Peroxisome morphology in pathology	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es