Publication: Neuropeptides in the seminal vesicles, locations, binding sites and functional implications
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Date
1997
Authors
Pinho, M.S. ; Afonso, F. ; Rodriguez, G. ; Gulbenkian, S. ; Mata, L.R.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The importance of neurona1 factors in the
normal physiology of the seminal vesicles has been
traditionally underestimated when compared to the
trophic role of androgens. Immunohistochemical,
autoradiographical and pharmacological experiments
have, however, raised the possibility that neuropeptides,
such as vasoactive intestinal polypeptide (VIP),
neuropeptide tyrosine (NPY) and calcitonin gene-related
peptide (CGRP), are necessary for full seminal vesicle
function and development. These neuropeptides may be
involved in the regulation of secretion, smooth muscle
tone and blood flow. Furthermore, neuropeptides may
have functional interactions with androgens affecting,
probably, androgen receptordependent gene expression
in these glands. It is now timely to focus attention on the
biological relevance of neuropeptides in the seminal
vesicles.
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