Publication: The localization of thrombospondin-1 (TSP-1), cysteine-serine-valine-threoninecysteine-
glycine (CSVTCG) TSP receptor, and
matrix metalloproteinase-9 (MMP-9) in colorectal cancer
Authors
Wakiyama, T. ; Shinohara, T. ; Shirakusa, T. ; John, A.S. ; Tuszynski, G.P.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Thrombospondin-1 (TSP-1) is a 450 kDa
matrix bound glycoprotein involved in tumor invasion,
metastasis, and angiogenesis. One of the receptors
involved in TSP-1 mediated tumor cell adhesion and
metastasis is the cysteine-serine-valine-threoninecysteine-
glycine (CSVTCG) receptor. One mechanism
of TSP-1 in promoting tumor cell metastasis involves the
up-regulation of matrix metalloproteinase-9 (MMP-9)
expression, specifically through the CSVTCG TSP-1
receptor. TSP-1 and its CSVTCG receptor has been
implicated in tumor progression in a variety of cancers
including breast adenocarcinomas, head and neck
squamous cell carcinomas, and pancreatic carcinomas.
In this study, we examined 99 cases of colorectal
cancer by immunohistochemical analysis to investigate
1) the localization of TSP-1 and CSVTCG TSP-1
receptor, 2) the relationship with MMP-9, and 3) the
correlation of expression with clinical staging.
Strong expression of TSP-1 was observed in the
submucosa or the serosa adjacent to the tumor. Positive
staining for CSVTCG TSP-1 receptor was observed in
tumor cells and microvessels. MMP-9 was also
expressed in tumor cells. In addition, staining intensity
of CSVTCG TSP-1 receptor was higher in poorly
differentiated adenocarcinoma than well or moderately
differentiated adenocarcinoma. Tumors in which
inflammatory cells stained strongly for CSVTCG TSP-1
receptor correlated with decreased incidence of distant metastasis and angiogenesis.
These data were consistent with our previous studies
for breast, pancreatic, and head and neck carcinoma.
They suggest an important role for TSP-1 and CSVTCG
TSP-1 receptor in tumor progression in colorectal
cancer.
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