Publication: Developmental pattern of three vesicular glutamate transporters in the myenteric plexus of the human fetal small intestine
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Date
2008
Authors
Linke, N. ; Bódi, N. ; Resch, B.E. ; Fekete, Eva ; Bagyánszki, M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Three vesicular glutamate transporters
(VGLUT1-3) have previously been identified in the
central nervous system, where they define the
glutamatergic phenotype, and their expression is tightly
regulated during brain development. In the present study
we applied immunocytochemistry to examine the
distribution of the immunoreactivity of all three
VGLUTs during prenatal development of the myenteric
plexus in the human small intestine. We also investigated
changes in their localization in the different segments of
the small intestine and in the different compartments of
the developing myenteric ganglia. Immunoreactivity
against all three VGLUTs was found predominantly in
the ganglionic neuropil, interganglionic varicose fibers
and perisomatic puncta, but cytoplasmic labeling with
different intensities also occurred. Each transporter
displayed a characteristic spatiotemporal expression
pattern, with the transient increase or decrease of
immunoreactive cell bodies, varicosities or perisomatic
puncta, depending on the fetal age, the gut segment or
the ganglionic compartment. Throughout gestational
weeks 14-23, VGLUT1 immunoreactivity always
predominated over VGLUT2 immunoreactivity, though
both peaked around week 20. VGLUT3 immunoreactivity was less abundant in the developing myenteric
plexus than those of VGLUT1 and VGLUT2
immunoreactivity. It was mainly expressed in the
ganglionic neuropil and in the perisomatic puncta
throughout the examined gestational period. Neuronal
perikarya immunoreactive for VGLUT3 were restricted
to between weeks 18 and 20 of gestation and exclusively
to the oral part of the small intestine.
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