Evaluation of heart fatty acid-binding protein as a biomarker for canine leishmaniosis

Casamián-Sorrosal, Domingo; Barrera-Chacón, Rafael; Fonfara, Sonia; Cristobal-Verdejo, Jose Ignacio; Talavera López, Jesús; Belinchón-Lorenzo, Silvia; Miró-Corrales, Guadalupe; Caro-Vadillo, Alicia; Duque, Francisco Javier

Publication:
Evaluation of heart fatty acid-binding protein as a biomarker for canine leishmaniosis

dc.contributor.author	Casamián-Sorrosal, Domingo
dc.contributor.author	Barrera-Chacón, Rafael
dc.contributor.author	Fonfara, Sonia
dc.contributor.author	Cristobal-Verdejo, Jose Ignacio
dc.contributor.author	Talavera López, Jesús
dc.contributor.author	Belinchón-Lorenzo, Silvia
dc.contributor.author	Miró-Corrales, Guadalupe
dc.contributor.author	Caro-Vadillo, Alicia
dc.contributor.author	Duque, Francisco Javier
dc.contributor.department	Medicina y Cirugía Animal
dc.coverage.spatial	España	es
dc.coverage.temporal	2023	es
dc.date.accessioned	2024-01-29T11:39:52Z
dc.date.available	2024-01-29T11:39:52Z
dc.date.issued	2023-05-20
dc.description	© 2023 British Veterinary Association. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the, Accepted, version of a Published Work that appeared in final form in Veterinary Record (VetRecord). To access the final edited and published work see: https://doi.org/10.1002/vetr.2683
dc.description.abstract	Background: Myocarditis frequently occurs in canine leishmaniosis (CanL). Heart fatty acid-binding protein (HFABP) is a biomarker of myocardial damage. Methods: This study aimed to compare HFABP concentration (HFABPc) in healthy dogs and dogs at different stages of CanL and evaluate the correlation of this biomarker with several clinicopathological and echocardiographic variables. Thirty-one dogs diagnosed with CanL and 10 healthy dogs were included. Results: HFABPc was not statistically different (p > 0.05) between groups of dogs at different LeishVet stages of CanL or between groups with high versus low to intermediate serology titres. In 70% of CanL dogs, HFABPc was within the 95% confidence interval limits of the mean of healthy dogs. A moderate negative correlation with globulin (r = -0.519; p = 0.03) and haematocrit (HCT) (r = -0.538; p = 0.02) was observed. No other significant correlation (p > 0.05) was observed with any other variable. Limitations: Many statistical tests were performed, and therefore, type I error cannot be ruled out. Conclusion: HFABPc is not consistently elevated in dogs with CanL and is not associated with the severity of the disease, or most echocardiographic or clinicopathological variables studied. The correlation with globulin and HCT was not strong and not considered clinically significant. HFABPc lacks sufficient predictive capacity in dogs with CanL, discouraging further research or clinical use of this biomarker in this disease.	es
dc.embargo.terms	2024-05-20
dc.format	application/pdf	es
dc.format.extent	11	es
dc.identifier.citation	Veterinary Record, 2023, Vol. 192, Issue10, e2683
dc.identifier.doi	https://doi.org/10.1002/vetr.2683
dc.identifier.issn	Print: 0042-4900
dc.identifier.issn	Electronic: 2042-7670
dc.identifier.uri	http://hdl.handle.net/10201/137940
dc.language	eng	es
dc.publisher	Wiley
dc.relation	Sin financiación externa a la Universidad	es
dc.relation.publisherversion	https://bvajournals.onlinelibrary.wiley.com/doi/10.1002/vetr.2683
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject.other	CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología	es
dc.subject.other	CDU::6 - Ciencias aplicadas::63 - Agricultura. Silvicultura. Zootecnia. Caza. Pesca::636 - Veterinaria. Explotación y cría de animales. Cría del ganado y de animales domésticos	es
dc.title	Evaluation of heart fatty acid-binding protein as a biomarker for canine leishmaniosis	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es