Publication: The roles and clinical significance of microRNAs in cervical cancer
Authors
Wang, Fenfen ; Li, Baohua ; Xie, Xing
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/HH-11-666
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info:eu-repo/semantics/article
Description
Abstract
Cervical carcinogenesis induced by
persistent human papillomavirus (HPV) infection
represents a stepwise progression from precursors to
invasive cervical cancer. Accumulated evidence has
shown aberrant expression of microRNAs (miRNAs) in
cervical cancer tissues and cells. Further studies reveal
that miRNAs play key roles in the initiation and
progression of cervical cancer, via specific signaling
pathways, including E6-p53, E7-pRb, phosphoinositide3 kinase (PI3K)-Akt, Notch, Wnt/β-catenin, and
Hedgehog pathways. Some studies demonstrate that
miRNAs might serve as biomarkers or therapeutic
targets, presenting a potential prospect in clinical
practice. All results provide new insights into the
function of miRNAs and the pathogenesis of cervical
cancer induced by viral oncoproteins. New approaches
for miRNA-based prevention and management for
cervical cancer will be developed in the future.
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Citation
Histology and Histopathology, vol.31, nº2, (2016)
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