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Blind deconvolution of second harmonic microscopy images of the living human eye

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dc.contributor.authorMugnier, Laurent M.
dc.contributor.authorMartínez Ojeda, Rosa María
dc.contributor.authorArtal Soriano, Pablo
dc.contributor.authorBueno García, Juan Manuel
dc.contributor.departmentFísica
dc.date.accessioned2026-01-16T07:18:15Z
dc.date.available2026-01-16T07:18:15Z
dc.date.copyright© 2023 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement
dc.date.issued2023-04-19
dc.description.abstractSecond harmonic generation (SHG) imaging microscopy of thick biological tissues is affected by the presence of aberrations and scattering within the sample. Moreover, additional problems, such as uncontrolled movements, appear when imaging in-vivo. Deconvolution methods can be used to overcome these limitations under some conditions. In particular, we present here a technique based on a marginal blind deconvolution approach for improving SHG images obtained in vivo in the human eye (cornea and sclera). Different image quality metrics are used to quantify the attained improvement. Collagen fibers in both cornea and sclera are better visualized and their spatial distributions accurately assessed. This might be a useful tool to better discriminate between healthy and pathological tissues, especially those where changes in collagen distribution occur.
dc.formatapplication/pdf
dc.format.extent12
dc.identifier.citationBiomedical Optics Express, 2023, Vol. 14, Issue 5, pp. 2117-2128
dc.identifier.doihttps://doi.org/10.1364/BOE.486989
dc.identifier.eissn2156-7085
dc.identifier.urihttp://hdl.handle.net/10201/187589
dc.languageeng
dc.publisherOptica Publishing Group
dc.relationAgencia Estatal de Investigación (PID2019-105684RB-I00/AEI/10.13039/501100011033, PID2020-113919RBI00/AEI/10.13039/501100011033).
dc.relation.publisherversionhttps://opg.optica.org/boe/fulltext.cfm?uri=boe-14-5-2117
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleBlind deconvolution of second harmonic microscopy images of the living human eye
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublicationes
relation.isAuthorOfPublication80be2390-46ed-4e4f-8ac2-625e43728a67
relation.isAuthorOfPublication460f1110-b358-474a-9e08-f92fabe4be2b
relation.isAuthorOfPublication.latestForDiscovery80be2390-46ed-4e4f-8ac2-625e43728a67
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