Publication: The effects of long-term low-protein intake on gastrin cells of the rat antral mucosa during adulthood
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Date
1996
Authors
Varagic, J. ; Koko, V. ; Todorovic, V. ; Bozovic, Z. ; Lackovic, V. ; Vuzevski, V.D.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The effect of experimental protein malnutrition
on gastrin producing cells in the antral part of
the stomach was studied in male Wistar rats.
Isoenergetic diets containing 25% (C-25) or 6% (PD-6)
were given in isocaloric amounts during a 4-month
experiment. All rats were offered drinking water ad
libitum. The results showed that the long-term protein
diet did not produce changes in the gastrin cell number.
At the ultrastructural level G cells exhibited a decreased
size of the nucleus. They were found to have an
increased total granule volume density but the volume
density of dense-cored granules was lower. The serum
gastrin levels were significantly lowered by feeding the
low protein diet. These changes are compatible with
decreased functional activity of G cells under long-term
protein deprivation.
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Citation
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