Publication: IGSF4: a new intercellular adhesion
molecule that is called by three names, TSLC1,
SgIGSF and SynCAM, by virtue of its diverse function
Authors
Watanabe, K. ; Ito, A. ; Koma, Y. ; Kitamura, Y.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Members of the immunoglobulin
superfamily often play key roles in intercellular
adhesion. IGSF4 is a novel immunoglobulin (Ig)-like
intercellular adhesion molecule. Three Ig-like domains
are included in the extracellular domain of IGSF4 and
mediate homophilic or heterophilic interactions
independently of Ca2+. The cytoplasmic domain of
IGSF4 contains the binding motifs that connect to actin
fibers. Since IGSF4 has been characterized by several
independent research groups, this molecule is called by
three names, TSLC1, SgIGSF and SynCAM. IGSF4 was
first characterized as a tumor suppressor of non-small
cell lung cancer and termed TSLC1, although how
IGSF4 suppresses tumor growth remains unknown.
Silencing of the IGSF4 gene was primarily achieved by
allelic loss and promoter methylation in this type of
cancers. Soon after this discovery, IGSF4 was found to
have roles in adhesion of spermatogenic cells to Sertoli
cells and mast cells to fibroblasts and termed SgIGSF.
Other researchers revealed that IGSF4 drives synaptic
formation of neural cells and termed it SynCAM.
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