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Histological grading in colorectal cancer: new insights and perspectives

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dc.contributor.authorBarresi, Valeria
dc.contributor.authorBonetti, Luca Reggiani
dc.contributor.authorLeni, Antonio
dc.contributor.authorCaruso, Rosario Alberto
dc.contributor.authorTuccari, Giovanni
dc.date.accessioned2020-09-23T14:03:09Z
dc.date.available2020-09-23T14:03:09Z
dc.date.issued2015
dc.description.abstractPoor histological differentiation is currently considered among the adverse histopathological factors associated with unfavourable clinical course of colorectal carcinoma (CRC). At present, the histological grade of CRC is assessed based on the percentage of glandular differentiation in the tumor according to the World Health Organization (WHO) criteria. However the prognostic value of the WHO grading system is limited by significant inter-observer variability in its assessment. In addition, the prognostic significance of WHO grading seems to depend on the microsatellite instability (MSI) status of the tumor. Finally, this grading does not apply to rarer histotypes of colorectal adenocarcinomas, such as the micropapillary, medullary, mucinous and signet ring cell variants. Recently a novel grading system based on the counting of clusters of five or more cells lacking a glandular structure (poorly differentiated clusters) and set in the tumor stroma or at invasive edge has been proposed in CRC. There is evidence that grading based on poorly differentiated clusters (PDC) is more reproducible and has more robust prognostic significance compared to WHO grading in CRC. In the present review we discuss the morphological features, criteria for the assessment, prognostic significance and correlation with biomolecular profiles of grading based on PDC counting in CRC.es
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.citationHistology and histopathology, Vol. 30, nº 9 (2015)
dc.identifier.doihttps://doi.org/10.14670/HH-11-633
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/96383
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectGradinges
dc.subjectColorectales
dc.subjectPDCes
dc.subjectMucinouses
dc.subjectMicropapillaryes
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes
dc.titleHistological grading in colorectal cancer: new insights and perspectiveses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.30, nº9 (2015)