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High expression of PKM2 as a poor prognosis indicator is associated with radiation resistance in cervical cancer

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dc.contributor.authorZhao, Yajie
dc.contributor.authorShen, Liangfang
dc.contributor.authorChen, Xi
dc.contributor.authorQian, Yujie
dc.contributor.authorZhou, Qin
dc.contributor.authorWang, Ying
dc.contributor.authorLi, Kai
dc.contributor.authorLiu, Miaomiao
dc.contributor.authorZhang, Sai
dc.contributor.authorHuang, Xinqiong
dc.date.accessioned2021-02-10T12:21:35Z
dc.date.available2021-02-10T12:21:35Z
dc.date.issued2015
dc.description.abstractOur study aimed to investigate the association of Pyruvate Kinase isozyme type M2 (PKM2) with radiation resistance in locally advanced cervical squamous cell carcinoma (LACSCC). We retros-pectively reviewed 132 female patients who received primary radiation therapy to treat LACSCC at Federation Internationale of Gynecologie and Obstetrigue（FIGO）stages IB-IVA. Forty-seven patients with progression free survival (PFS) of less than 36 months were regarded to have radiation resistance. Eighty-five patients with PFS no less than 36 months were regarded as radiation sensitive. Using immunohistochemistry, we found that the overexpression rate of PKM2 in radiation resistant and radiation sensitive patients was 87.2% and 57.6%, respectively, and the difference was statistically significant (p＜0.001). The 5-year progress free survival rates in patients with low and high expression of PKM2 was 80.4% and 60.5%, respectively, and the difference was statistically significant (p=0.008). Multivariate Cox regression analysis identified that high expression of PKM2 is an independent negative prognostic factor in cervical cancer patients [Hazard ratio (95% CI), 2.888 (1.347, 6.194) p=0.006]. These results demonstrate that overexpression of PKM2 contributes to radiation resistance and acts a poor prognosis indicator in patients with LACSCC.es
dc.formatapplication/zipes
dc.format.extent8es
dc.identifier.citationHistology and Histopathology, vol. 30, nº 11, (2015)
dc.identifier.doi10.14670/HH-11-627
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/103005
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectLocally advanced cervical squamous cell carcinomaes
dc.subjectRadiation resistancees
dc.subjectGlycolysises
dc.subjectPKM2es
dc.subjectImunohistochemistryes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleHigh expression of PKM2 as a poor prognosis indicator is associated with radiation resistance in cervical canceres
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.30,nº11 (2015)