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Effects of topical applications of porcine acellular urinary bladder matrix and Centella asiatica extract on oral wound healing in a rat model

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dc.contributor.authorCamacho Alonso, Fabio
dc.contributor.authorTorralba Ruiz, M. R.
dc.contributor.authorGarcía Carrillo, N.
dc.contributor.authorLacal Luján, J.
dc.contributor.authorMartínez Díaz, F.
dc.contributor.authorSánchez Siles, M.
dc.contributor.departmentOftalmología, Optometría, Otorrinolaringología y Anatomía Patológica
dc.date.accessioned2024-11-14T12:07:27Z
dc.date.available2024-11-14T12:07:27Z
dc.date.issued2019
dc.description© 2018, Springer-Verlag GmbH Germany, part of Springer Nature. This document is the Published version of a Published Work that appeared in final form in Clinical Oral Investigations. To access the final edited and published work see https://link.springer.com/article/10.1007/s00784-018-2620-xes
dc.description.abstractObjectives To evaluate the effects of topical applications of porcine acellular urinary bladder matrix (AUBM) and Centella asiatica extract (CAE) on the healing of tongue wounds in a rat model. Materials and methods Wounds were made in the tongue using a punch tool in 64 male Sprague-Dawley rats, randomized into four groups (n = 16 per group): group 1 (control), group 2 (CAE), group 3 (AUBM mixed with orabase), and group 4 (orabase). No product was applied in group 1 and groups 2–4 received three daily topical applications. The animals were weighed on day 0 and at the time of euthanasia. Four rats in each group were euthanized at days 2, 7, 14, and 21 and the tongues were processed for: macroscopic morphometric analysis, myeloperoxidase (MPO) and malondialdehyde (MDA) levels, histological wound repair (degree of reepithelialization and inflammation), and CD31 positivity. Results The animals’ weight gain, histological wound repair, and CD31 positivity from greatest to least were: AUBM > CAE > orabase > control. Percentage of tongue occupied by wound, MPO, and MPA levels from least to greatest were: AUBM < CAE < orabase < control, whereby the AUBM group showed significant differences (p ≤ 0.05) in comparison with the other groups on days 2, 7, 14, and 21 for percentage of tongue occupied by wound and MDA and on days 7, 14, and 21 for MPO. Conclusions CAE is effective for oral tissue regeneration, while AUBM is an even more potent means of oral mucosa regeneration. Clinical relevance AUBM may be beneficial to patients with oral wounds; this finding requires further clinical and laboratory investigation.es
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dc.format.extent13es
dc.identifier.citationClinical Oral Investigations, 2019, Vol. 23, pp. 2083–2095
dc.identifier.doihttps://doi.org/10.1007/s00784-018-2620-x
dc.identifier.issnPrint: 1432-6981
dc.identifier.issnElectronic: 1436-3771
dc.identifier.urihttp://hdl.handle.net/10201/146309
dc.languageenges
dc.publisherSpringeres
dc.relationSin financiación externa a la Universidades
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s00784-018-2620-xes
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectPorcine acellular urinary bladder matrixes
dc.subjectCentella asiatica extractes
dc.subjectWound healinges
dc.subjectOral mucosaes
dc.subjectRat modeles
dc.titleEffects of topical applications of porcine acellular urinary bladder matrix and Centella asiatica extract on oral wound healing in a rat modeles
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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