Publication: Comparative analysis of cell populations involved in the proliferative and inflammatory processes in
diffuse and localised pigmented villonodular synovitis
Authors
Berger, I. ; Ehemann, V. ; Helmchen, B. ; Penzel, R. ; Weckauf, H.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
The aim of the present study was a
comparative quantitative evaluation of cell populations
involved in the proliferative and inflammatory
compartment in both localised and diffuse pigmented
synovitis villonodularis (PVNS). 15 cases of each
localised and diffuse PVNS were examined by flow
cytometry, immunohistochemistry, double immunofluorescence
and confocal microscopy with quantitative
evaluation of CD3-, CD4-, CD8-, CD20-, CD57-,
CD55-, CD68-, CD163- and h4Ph positive (+) cells. The
proliferative compartment of localised and diffuse PVNS
was mainly composed of double-positive CD68+/h4Ph+
(CD163+/CD55+) synoviocytes. The number of doublepositive
synoviocytes for macrophage and fibroblast
markers was significantly higher in diffuse compared to
localised PVNS. The accompanying inflammatory
infiltrate showed a predominance of cytotoxic cells
(CD8+, CD57+), whereby the number of CD3+ and
CD20+ cells was significantly higher in localised PVNS.
The number of CD57+ NK cells was significantly higher
in diffuse PVNS. The proliferating macrophage- like
synovial cells and the cytotoxic lymphocytes could
contribute to the aggressive behaviour of localised and
diffuse PVNS. Moreover, with regard to the quantitative
differences in cell composition between diffuse and
localised PVNS and their different clinical behaviour, further studies should continue to analyse localised and
diffuse PVNS separately.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.