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Epidemiology, evolution, and long-term survival of alcoholic cirrhosis patients submitted to liver transplantation in southeastern Spain

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dc.contributor.authorNavarro Noguera, Elena
dc.contributor.authorBolarín, Jose M.
dc.contributor.authorGarcía Alonso, Ana M.
dc.contributor.authorLuna Maldonado, Aurelio
dc.contributor.authorMrowiec, Anna
dc.contributor.authorCampillo, José Antonio
dc.contributor.authorMoya Quiles, Rosa
dc.contributor.authorÁlvarez López, María del Rocio
dc.contributor.authorMinguela Puras, Alfredo
dc.contributor.authorMiras, Manuel
dc.contributor.authorSánchez Bueno, Francisco
dc.contributor.authorMuro, Manuel
dc.contributor.authorGimeno Arias, Lourdes
dc.contributor.authorLegaz Pérez, Isabel
dc.contributor.departmentCiencias Sociosanitarias
dc.date.accessioned2024-07-12T08:34:20Z
dc.date.available2024-07-12T08:34:20Z
dc.date.issued2016-04
dc.description© 2016 by the Research Society on Alcoholism. This document is the Published version of a Published Work that appeared in final form in Alcoholism: Clinical and Experimental Research. To access the final edited and published work see https://doi.org/10.1111/acer.13013
dc.description.abstractBackground Alcoholic cirrhosis (AC) is a common cause of death among individuals abusing alcohol. In the last resort, liver transplantation (LT) is considered the only solution to save the patient's life, generating socioeconomic and public health problems. Clinical and sociodemographic characteristics, rejection frequency, and short- and long-term graft survival are not well known in end-term AC patients undergoing LT. The aim was to determine the sociodemographic and clinical characteristics, their incidence in LT, main pre- and posttransplant complications, and short- and long-term post-transplant graft survival in AC patients in southeastern Spain. Methods The medical records of 1,026 patients who underwent LT over the last 23 years were retrospectively reviewed, and demographic data and posttransplant survivals were analyzed and compared. Biochemical characteristics, major pre- and posttransplant complications and short- and long-term survivals were analyzed in a total of 398 male patients with AC undergoing LT. Results AC and viral cirrhosis are the main indications for LT in our study. Mostly represented in our study are AC men without associated viral infections with a mean age of 53.06 years. Main pretransplant complications in AC patients are ascites (78.3%) and encephalopathy (43.5%), while acute graft rejection is the most common liver posttransplant complication (26.6%), nevertheless with low graft loss frequency (1.1%). AC and autoimmune cirrhosis show the best posttransplant survival in both the short and long term. Patients with AC included on the waiting list for LT were Child-Pugh class B (52.1%) and Model for End-Stage Liver Disease score of 10 to 19 (71.2%). The highest percentage of AC patient survival was observed at 1 year posttransplant (81.2%) and progressively decreased over time up to 10 years posttransplant (69.6%). Pretransplant complications such as ascites and encephalopathy did not have an influence on the percentage of posttransplant survivals, although better survival rates were observed in nonviral AC patients. Conclusions AC without viral infections is the main indication for LT in southeastern Spain although its frequency has decreased in last decade. AC is a good indication for LT for its high survival rate and few posttransplant complications. Despite having a high percentage of pretransplant complications (ascites and encephalopathy) but does not appear to influence survivals being observed posttransplant survival rates above those expected. Conversely, viral infections in the patient with AC decrease patient survivals. The main future goals are design new strategies to detect, treat, and reduce AC frequency in our population and know alcoholic recidivism rate posttransplant in our population.es
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dc.format.extent12es
dc.identifier.citationAlcoholism: Clinical and Experimental Research, 2016, Vol. 40, Issue 4, pp. 794-805
dc.identifier.doihttps://doi.org/10.1111/acer.13013
dc.identifier.issnPrint: 0145-6008
dc.identifier.issnElectronic: 1530-0277
dc.identifier.urihttp://hdl.handle.net/10201/143054
dc.languageenges
dc.publisherWiley
dc.relationThis work was supported by excellence project of Seneca (GERM/06/2008), CajaMurcia Fundations, Instituto de Salud Carlos III (ISCiii) Project FISPI13/02297 and PI15/01370, and Association Pablo Ugarte (APU). IL was financed by the Sara Borrell Program from the Fondo de Investigación Sanitaria del ISCiii, Ministerio de Economía y Competitividad, Spain. LG was supported by ISCiii (CA09/00099), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD) and Programa Nacional de Movilidad de Recursos Humanos, Plan Nacional de I-D+i 2008-2011, Ministerio de Educación.es
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/full/10.1111/acer.13013
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectAlcoholes
dc.subjectAlcoholic Cirrhosises
dc.subjectLiver transplantes
dc.subjectSurvivales
dc.subjectModel for End-Stage Liver Diseasees
dc.titleEpidemiology, evolution, and long-term survival of alcoholic cirrhosis patients submitted to liver transplantation in southeastern Spaines
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicationa0170301-b64f-46f8-810a-ff18c9bf0a5f
relation.isAuthorOfPublicationb83b4b59-2d61-40f0-9108-5c6a6d158295
relation.isAuthorOfPublication.latestForDiscoverya0170301-b64f-46f8-810a-ff18c9bf0a5f
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