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Patient sex in the setting of liver transplant in alcoholic liver disease

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dc.contributor.authorNavarro Noguera, Elena
dc.contributor.authorBolarín, Jose Miguel
dc.contributor.authorCampillo, Jose Antonio
dc.contributor.authorMoya, Rosa
dc.contributor.authorLuna, Aurelio
dc.contributor.authorMiras, Manuel
dc.contributor.authorMinguela, Alfredo
dc.contributor.authorÁlvarez López, María Rocio
dc.contributor.authorMuro, Manuel
dc.contributor.authorLegaz Pérez, Isabel
dc.contributor.departmentCiencias Sociosanitarias
dc.date.accessioned2024-07-12T07:53:54Z
dc.date.available2024-07-12T07:53:54Z
dc.date.issued2019-06
dc.description© Baskent University 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Published version of a Published Work that appeared in final form in Experimental and Clinical Transplantation. To access the final edited and published work see https://doi.org/10.6002/ect.2017.0302
dc.description.abstractObjectives: The aim of this study was to analyze alcoholic cirrhosis in women who were to undergo liver transplant, including their biochemical and clinical characteristics, main complications, survival rates, and main causes of death compared with men with alcoholic cirrhosis. Materials and Methods: Our study included 400 patients with alcoholic cirrhosis, which we divided according to sex and viral infections. Biochemical parameters and the presence and degree of ascites and encephalopathy, liver function status, and liver rejection and survivalrates were analyzed from 1 to 10 years and the main cause of death at 10 years. Results: Patients with nonviral alcoholic cirrhosis and liver transplant had significantly better survival rates (84.1%) at 1 year versus those with viral alcoholic cirrhosis (74.5%; P = .036). Men with nonviral alcoholic cirrhosis (14%) and women with hepatitis C virus (29%) had the lowest short-term survival rates. In long-term survival analysis, the lowest rate was observed in women with nonviral alcoholic cirrhosis (26.1%), and the highest rate was observed in women with hepatitis C virus (42.9%). Liver graft failure was one of the main causes of death in male patients (19.5%). Conclusions: Women with alcoholic cirrhosis showed a higher rate of ascites and encephalopathy but lower liver graft rejection than men with alcoholic cirrhosis. Survival rates were similar between men and women, although slightly lowerin women who had hepatitis C virus.es
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dc.identifier.citationExperimental and Clinical Transplantation, 2019, 17(3), pp. 355-362.
dc.identifier.doihttps://doi.org/10.6002/ect.2017.0302
dc.identifier.issnPrint: 1304-0855
dc.identifier.issnElectronic: 2146-8427
dc.identifier.urihttp://hdl.handle.net/10201/143041
dc.languageenges
dc.publisherBaskent University
dc.relationThis work was supported by an excellence project of the Seneca under grant GERM/06/2008 and the Caja Murcia Fundations and Instituto de Salud Carlos III (ISCiii) Projects FISPI13/02297 and PI15/01370. I. Legaz was financed by the Sara Borrell Program from the Fondo de Investigación Sanitaria del ISCiii, Ministerio de Economía y Competitividad, Spain. The authors thank the Immunology and Digestive Services Department of the Virgen de la Arrixaca University Hospital (Murcia, Spain) for their kind collaboration.es
dc.relation.publisherversionhttps://www.ectrx.org/detail/archive/2019/17/3/0/355/0
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAlcoholes
dc.subjectAlcoholic cirrhosises
dc.subjectHuman clinical toxicologyes
dc.subjectLiver transplantes
dc.subjectPosttransplant survivales
dc.titlePatient sex in the setting of liver transplant in alcoholic liver diseasees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicationb83b4b59-2d61-40f0-9108-5c6a6d158295
relation.isAuthorOfPublication.latestForDiscoveryb83b4b59-2d61-40f0-9108-5c6a6d158295
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