Cephalosporin susceptibility of Staphylococcus aureus strains isolated from commercial rabbit and goat farms in Spain

Badillo Puerta, Elena; Escudero, Elisa; Galecio, Juan Sebastian; Marín, Pedro

Publication:
Cephalosporin susceptibility of Staphylococcus aureus strains isolated from commercial rabbit and goat farms in Spain

dc.contributor.author	Badillo Puerta, Elena
dc.contributor.author	Escudero, Elisa
dc.contributor.author	Galecio, Juan Sebastian
dc.contributor.author	Marín, Pedro
dc.contributor.department	Farmacología
dc.date.accessioned	2025-03-21T08:24:39Z
dc.date.available	2025-03-21T08:24:39Z
dc.date.issued	2022-12-31
dc.description	© 2022, Elena Badillo, Elisa Escudero, Juan Sebastián Galecio, Verónica Hernandis, Pedro Marin. This manuscript version is made available under the CC-BY-NC 4.0 license http://creativecommons.org/licenses/by-nc/4.0/. This document is the Published version of a Published Work that appeared in final form in Veterinaria Italiana. To access the final edited and published work see https://doi.org/10.12834/VetIt.2241.16176.1
dc.description.abstract	Antimicrobial drug resistance is an important problem that challenges veterinary clinicians to provide effective treatments without further spreading this resistance to other animals and people. The most commonly used pharmacodynamic parameter to define potency of antimicrobial drugs is minimum inhibitory concentration (MIC). The aim of this study was to evaluate the antibiotic susceptibility of thirty-six strains of Staphylococcus aureus isolated from dairy goats with mastitis and rabbits with chronic staphylococcosis. Four cephalosporins were tested: cephalexin, cephalotin, cefonicid and ceftiofur. MIC tests were performed according to the microdilution broth method. The calculated values of sensitivity in goats and rabbits were 66.67% and 72.22% for cephalexin, 72.22 % and 94.44% for cefonicid, 77.78% and 94.44% for cephalotin and 77.78% and 100% for ceftiofur, respectively. For all antibiotics, MIC90 of S. aureus from rabbits were lower than MIC90 from goats. These data suggest that more antibiotics are used in goat milk production than in rabbit farming. According to MIC values obtained in this study, ceftiofur and cephalotin may be the best option for treating S. aureus infections in lactating goats. For rabbits, ceftiofur showed lowest MIC values, but cephalosporins can produce fatal diarrhoea in this species, therefore additional studies are needed to evaluate the effects of repeated ceftiofur administration on microflora of rabbits before recommending the use of this antibiotic in this species.
dc.format	application/pdf	es
dc.format.extent	5	es
dc.identifier.citation	Veterinaria Italiana 2022, 58 (3), 325-329
dc.identifier.doi	https://doi.org/10.12834/VetIt.2241.16176.1
dc.identifier.issn	Electronic: 1828-1427
dc.identifier.uri	http://hdl.handle.net/10201/152003
dc.language	eng	es
dc.publisher	Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise 'G. Caporale'
dc.relation	Sin financiación externa a la Universidad	es
dc.relation.publisherversion	https://www.veterinariaitaliana.izs.it/index.php/VetIt/article/view/2241
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Atribución-NoComercial 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc/4.0/	*
dc.subject	Cefonicid	es
dc.subject	Cephalosporins
dc.subject	Staphylococcus aureus
dc.subject	Minimum inhibitory
dc.subject	Concentration (MIC)
dc.subject	Goats
dc.subject	Rabbits
dc.title	Cephalosporin susceptibility of Staphylococcus aureus strains isolated from commercial rabbit and goat farms in Spain	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es