Publication: Apocrine secretory mechanism:
Recent findings and unresolved problems
Authors
Gesase, A.P. ; Satoh, Y.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Cell secretion is an important physiological
process that ensures smooth metabolic activities, tissue
repair and growth and immunological functions in the
body. It occurs when the intracellular secretory materials
are released to the exterior; these may be in the form of
lipids, protein or mucous and may travel through a duct
system or via blood to reach the target organ. To date
three types of secretory mechanisms have been
characterized, they include apocrine, holocrine and
exocytosis. Apocrine secretion occurs when the release
of secretory materials is accompanied with loss of part
of cytoplasm. The secretory materials may be contained
in the secretory vesicles or dissolved in the cytoplasm
that is lost during secretion. In holocrine secretion, the
entire cell is secreted into the glandular lumen, and it is
presumed that the intended secretory materials are
contained in the cell cytoplasm. Exocytosis is the most
commonly occurring type of secretion; here the
secretory materials are contained in the secretory
vesicles and released without loss of cytoplasm.
Apocrine secretory mechanisms have not been properly
discussed; for example the biochemical and
physiological pathways that regulate apocrine secretory
process are not clearly known. Similarly, the plasma
membrane dynamics during apocrine secretion has not
been researched. In other glands morphological features
during apocrine secretion have not been documented.
The current paper reviews what is known about apocrine
secretion, recent findings and highlights on the
unresolved areas for future research.
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