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Characterization of a murine model of intranasal infection suitable for testing vaccines against C. abortus

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dc.contributor.authorNicolás, L.
dc.contributor.authorGallego, M. C.
dc.contributor.authorSánchez, J.
dc.contributor.authorCaro, M. R.
dc.contributor.authorSalinas, J.
dc.contributor.authorMartínez Cáceres, Carlos Manuel
dc.contributor.authorNavarro Cámara, José Antonio
dc.contributor.authorOrtega Hernández, Nieves
dc.contributor.authorBuendía Marín, Antonio Julián
dc.contributor.departmentAnatomía y Anatomía Patológica Comparadas
dc.date.accessioned2025-01-21T09:18:04Z
dc.date.available2025-01-21T09:18:04Z
dc.date.issued2007-01-15
dc.description© 2006 Elsevier B.V. This document is the Published version of a Published Work that appeared in final form in Veterinary Immunology and Immunopathology. To access the final edited and published work see https://doi.org/10.1016/j.vetimm.2006.10.008es
dc.description.abstractMouse models have been widely used to test candidate vaccines against Chlamydophila abortus infection in mice. Although the induction of a systemic infection by endogenous or intraperitoneal inoculation is a useful tool for understanding the immune mechanism involved in the protection conferred by the vaccination, a different approach is necessary to understand other factors of the infection, such as mucosal immunity or the colonization of target organs. To test whether C. abortus intranasal model of infection in mice is a useful tool for testing vaccines in a first group of experiments mice, were infected intranasally with C. abortus to characterize the model of infection. When this model was used to test vaccines, two inactivated experimental vaccines, one of them adjuvated with QS-21 and another with aluminium hydroxide, and a live attenuated vaccine (strain 1B) were used. Non-vaccinated control mice died within the first 8 days, after displaying substantial loss of weight. Histologically, the mice showed lobar fibrinopurulent bronchointerstitial pneumonia. Prior immunization with QS-21 adjuvated vaccine or 1B vaccine presented mortality and the recipients showed a greater number of T cells in the lesions, especially CD8+ T cells, than the control mice and mice immunized with vaccine adjuvated with aluminium hydroxide. The results confirm that the C. abortus intranasal model of infection in mice is a useful tool for testing vaccineses
dc.formatapplication/pdfes
dc.format.extent11es
dc.identifier.citationVeterinary Immunology and Immunopathology, 2007, Vol. 115, Issues 1–2, pp. 76-86
dc.identifier.doihttps://doi.org/10.1016/j.vetimm.2006.10.008
dc.identifier.issnPrint: 0165-2427
dc.identifier.issnElectronic: 1873-2534
dc.identifier.urihttp://hdl.handle.net/10201/148891
dc.languageenges
dc.publisherElsevieres
dc.relationThis work was supported partially by a grant from Ministerio de Educación y Ciencia co-financed with FEDER funds (AGL2004-06571). C.M. Martínez was the recipient of a predoctoral grant from Ministerio de Educación y Ciencia. N. Ortega was the recipient of a postdoctoral grant from the Universidad de Murcia.es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0165242706002820es
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectChlamydophila abortuses
dc.subjectMouse modeles
dc.subjectAdjuvantses
dc.subjectVaccinees
dc.subjectCellular immune responsees
dc.titleCharacterization of a murine model of intranasal infection suitable for testing vaccines against C. abortuses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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relation.isAuthorOfPublication.latestForDiscoverya11bfbe4-fe50-4173-a96d-aa785375a6be
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