Publication: Histopathological, immunohistochemical, and stereological analysis of the effect of Ginkgo biloba (Egb761) on the hippocampus of rats exposed to long-term cellphone radiation
Authors
Gevrek, Fikret
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Publisher
Universidad de Murcia. Departamento de BiologĂa Celular e HistologĂa
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DOI
DOI: 10.14670/HH-11-943
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info:eu-repo/semantics/article
Description
Abstract
Cellular phones are major sources of
electromagnetic radiation (EMR) that can penetrate the
human body and pose serious health hazards. The
increasingly widespread use of mobile communication
systems has raised concerns about the effects of
cellphone radiofrequency (RF) on the hippocampus
because of its close proximity to radiation during
cellphone use. The effects of cellphone EMR exposure
on the hippocampus of rats and the possible
counteractive effects of Ginkgo biloba (Egb761) were
aimed to investigate. Rats were divided into three
groups: Control, EMR, and EMR+Egb761. The EMR
and EMR+Egb761 groups were exposed to cellphone
EMR for one month. Egb761 was also administered to
the EMR+Egb761 group. Specifically, we evaluated the
effect of RF exposure on rat hippocampi at harmful
EMR levels (0.96 W/kg specific absorption rate [SAR])
for one month and also investigated the possible impact
of Egb761 using stereological, TUNEL-staining, and
immunohistochemical methods. An increase in apoptotic
proteins (Bax, Acas-3) and a decrease in anti-apoptotic
protein (Bcl-2) immuno-reactivity along with a decrease
in the total granule and pyramidal cell count were noted
in the EMR group. A decrease in Bax and Acas-3 and an
increase in Bcl-2 immunoreactivity were observed in
rats treated with Egb761 in addition to a decrease in
TUNEL-stained apoptotic cells and a higher total viable
cell number. In conclusion, chronic cellphone EMR
exposure may affect hippocampal cell viability, and
Egb761 may be used to mitigate some of the deleterious
effects.
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Citation
Histology and Histopathology, Vol.33, nÂş5, (2018)
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