Publication: Induction of NADPH diaphoraselnitric oxide
synthase in the spinal cord motor neurons of rats
following a single and multiple non-penetrative blasts
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Date
1999
Authors
Kaur, C. ; Singh, J. ; Moochhala, S. ; Lim, M.K. ; Lu, J. ; Ling, E. A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The present study has demonstrated the
induction of nicotinamide adenine dinucleotide
phosphate-diaphorase (NADPH-d) reactivity and nitric
oxide synthase-like immunoreactivity (NOS-LI) in the
ventral horn motoneurons of the spinal cord in rats
subjected to a single or multiple underground, or a single
surface blast. Both enzyme activities were first detected
in some motoneurons in laminae V111 and IX of Rexed,
3 hours after the blast. Some NADPH-d and NOS-L1
positive neurons were also distributed in laminae V1 and
V11. The number and intensity of the labelled cells
appeared to increase progressively, peaking at 2-3 days
after the blast but were drastically reduced thereafter, so
that at 7 days after the blast only a few positive neurons
were observed. In rats killed at 2 weeks and in longer
surviving intervals, i.e. up to 1 month, NADPH-d/NOS
reactivity in the ventral horn motor neurons had
diminished. The functional significance of the transient
expression of neuronal NADPH-d/NOS after the blasts
remains uncertain, although from a speculative point of
view, the induction of these enzymes probably would
reflect an increased production of nitric oxide (NO). In
view of the lack of atrophic changes in most, if not all,
of motor neurons, it is suggested that the increased levels
of NO production after the blast injury may be involved
in a neuroprotective function.
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