Publication: Heterotopic neogenesis of skeletal muscle induced in the adult rat diaphragmatic peritoneum. Ultrastructural and transplantation studies
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Date
1999
Authors
Drakontides, A.B. ; Danon, M.J. ; Levine, S.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
During the course of a mild chemical
peritonitis, new skeletal muscle fibers develop and
persist over a twelve-month interval in the diaphragmatic
peritoneum. Light and electron microscopic
studies revealed that the ectopic fibers developed from
myoblasts and myotubes to fully differentiated muscle
cells in the same manner as normally situated skeletal
muscle. The ectopic fibers were separated from the
intrinsic muscle by dense connective tissue and an
elastic lamina. Diaphragms taken from normal rats and
transplanted to the omentum of isogeneic recipients also
developed skeletal muscle neogenesis in the same
ectopic location as in the normal diaphragm. Satellite
cells, reactive fibroblasts in the peritoneum, mesenchymal
stem cells or blood-borne myoblast precursor
cells could be the source of these ectopic muscle fibers.
The results of the present studies, however, cannot
provide conclusive evidence for the origin of the
new muscle fibers. Regardless of their source, the
methods employed may represent a unique model
for the development and prolonged maintenance
of skeletal muscle fibers in a heterotopic location in
vivo.
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