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Brassica bioactives could ameliorate the chronic inflammatory condition of endometriosis

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dc.contributor.authorGarcía-Ibañez, Paula
dc.contributor.authorYepes-Molina, Lucía
dc.contributor.authorRuiz Alcaraz, Antonio José
dc.contributor.authorMartínez-Esparza Alvargonzález, María Concepción
dc.contributor.authorMoreno, Diego A.
dc.contributor.authorCarvajal, Micaela
dc.contributor.authorGarcía Peñarrubia, María del Pilar
dc.contributor.departmentBioquímica y Biología Molecular B e Inmunología
dc.contributor.otherFacultad de Biología
dc.date.accessioned2026-01-12T11:15:54Z
dc.date.available2026-01-12T11:15:54Z
dc.date.copyright© 2020 by the authors
dc.date.issued2020-12-10
dc.description.abstractEndometriosis is a chronic, inflammatory, hormone-dependent disease characterized by histological lesions produced by the presence of endometrial tissue outside the uterine cavity. Despite the fact that an estimated 176 million women are affected worldwide by this gynecological disorder, risk factors that cause endometriosis have not been properly defined and current treatments are not efficient. Although the interaction between diet and human health has been the focus of many studies, little information about the correlation of foods and their bioactive derivates with endometriosis is available. In this framework, Brassica crops have emerged as potential candidates for ameliorating the chronic inflammatory condition of endometriosis, due to their abundant content of health-promoting compounds such as glucosinolates and their hydrolysis products, isothiocyanates. Several inflammation-related signaling pathways have been included among the known targets of isothiocyanates, but those involving aquaporin water channels have an important role in endometriosis. Therefore, the aim of this review is to highlight the promising effects of the phytochemicals present in Brassica spp. as major candidates for inclusion in a dietary approach aiming to improve the inflammatory condition of women affected with endometriosis. This review points out the potential roles of glucosinolates and sothiocyanates from Brassicas as anti-inflammatory compounds, which might contribute to a reduction in endometriosis symptoms. In view of these promising results, further investigation of the effect of glucosinolates on chronic inflammatory diseases, either as diet coadjuvants or as therapeutic molecules, should be performed. In addition, we highlight the involvement of aquaporins in the maintenance of immune homeostasis. In brief, glucosinolates and the modulation of cellular water by aquaporins could shed light on new approaches to improve the quality of life for women with endometriosis.
dc.formatapplication/pdf
dc.format.extent20
dc.identifier.citationInt. J. Mol. Sci. 2020, 21, 9397
dc.identifier.doihttps://doi.org/10.3390/ijms21249397
dc.identifier.eissn1422-0067
dc.identifier.issn1661-6596
dc.identifier.urihttp://hdl.handle.net/10201/185689
dc.languageeng
dc.publisherMDPI
dc.relationThis work was funded by Fundación Seneca—Murcia Regional Agency for Science and Technology through the Project Ref. 20855/PI/18. P.G.-I. was funded by a grant from the Fundación Séneca-CARM, Spain (21273/FPI/19), and L.Y.-M. was funded by a grant from the Spanish Ministerio de Ciencia, Educación y Universidades (FPU17/02261). This work was also partially supported by the Spanish Ministerio de Economía, Industria y Competitividad under Grant AGL2016-80247-C2-1-R.
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/21/24/9397
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectBrassica
dc.subjectIndoles
dc.subjectIsothiocyanates
dc.subjectEndometriosis
dc.subjectInflammation
dc.subjectAquaporins
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleBrassica bioactives could ameliorate the chronic inflammatory condition of endometriosis
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublicationes
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relation.isAuthorOfPublication79449fb4-f715-4255-a064-bfecc4b502de
relation.isAuthorOfPublication37ff1b37-1579-4eb9-b618-68868c3e2665
relation.isAuthorOfPublication.latestForDiscoveryc5d54ef3-bd3b-4330-b4a1-252ab278925b
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