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Pathogenesis of spinal intramedullary lipomas: two case reports

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dc.contributor.authorMoreno Gómez, Luis Miguel
dc.contributor.authorGarcía Pérez, Daniel
dc.contributor.authorGonzález‑León, Pedro Juan
dc.contributor.authorMunarriz, Pablo M.
dc.contributor.authorCastaño‑León, Ana María
dc.contributor.departmentFarmacología
dc.contributor.otherFarmacia
dc.date.accessioned2026-02-23T13:19:06Z
dc.date.available2026-02-23T13:19:06Z
dc.date.copyright© 2023 The Author(s)
dc.date.issued2023-07-25
dc.description.abstractBackground: Spinal lipomas not associated with dysraphism are rare and have an unknown natural history. In this report, we describe two cases; they showed recurrence during long-term follow-up, which makes us doubt a benign malformative etiology. Case reports: Two patients, a 19-year-old South American woman and a 14-year-old boy with spinal lipomas, underwent surgical resection. The lipomas were not associated with dysraphism and were located in the cervicothoracic and craniocervical junctions. In both cases, we decided to operate due to clinical progression; the former had a progressive natural course, and the latter experienced clinical worsening after recurrence from previous surgeries. The surgery took place with the assistance of neurophysiological monitoring and intraoperative ultrasound; a partial resection and medullary decompression were done, following the more recent recommendations. Discussion: The natural history of these lesions is currently unknown due to their rarity and the heterogeneity in the long-term follow-up of previously reported cases. Although previous reports describe good outcomes after surgical resection, long follow-ups, especially in young subjects, may show differences in these outcomes with progression and recurrence. We contribute to this last piece of evidence by describing two more cases of progression and recurrence. : Lessons: Long-term close follow-up should be done in young subjects with spinal lipomas, as they are more prone to an aggressive course. Metabolism and hormonal changes may be behind this progression. Reoperation must be considered if neurological decline is detected.
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dc.identifier.citationMoreno Gómez LM, García-Pérez D, González-León PJ, Munarriz PM, Castaño-León AM. Pathogenesis of spinal intramedullary lipomas: two case reports. J Med Case Rep. 2023 Jul 25;17(1):317. doi: 10.1186/s13256-023-04048-z.
dc.identifier.doihttps://doi.org/10.1186/s13256-023-04048-z
dc.identifier.eissn1752-1947
dc.identifier.urihttp://hdl.handle.net/10201/211001
dc.languageeng
dc.publisherBioMed Central
dc.relationSin financiación externa a la Universidad
dc.relation.publisherversionhttps://link.springer.com/article/10.1186/s13256-023-04048-z
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectLipomas
dc.subjectDysraphism
dc.subjectRecurrence
dc.subjectMalformation
dc.subjectMetabolism
dc.subjectSpine
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titlePathogenesis of spinal intramedullary lipomas: two case reports
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublicationes
relation.isAuthorOfPublication2f2500a1-1b27-4420-820c-db8c16e79afd
relation.isAuthorOfPublication.latestForDiscovery2f2500a1-1b27-4420-820c-db8c16e79afd
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