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Immunoexpression of adhesion molecules during human fetal hair development

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dc.contributor.authorAndrade Silva, Laura Maria
dc.contributor.authorHsieh, Ricardo
dc.contributor.authorLourenço, Silvia Vanessa
dc.contributor.authorOttoni, Verônica
dc.contributor.authorValente, Neusa
dc.contributor.authorDumet Fernandes, Juliana
dc.date.accessioned2022-12-02T10:09:39Z
dc.date.available2022-12-02T10:09:39Z
dc.date.issued2020
dc.description.abstractIntroduction. Hair follicles are produced in a cyclical manner and the machinery involved in the reproduction of these follicles is present since the fetal stage. Although extensive research has been done on the human hair follicle, very little is known about the importance of adhesion molecules in its development. Material and methods. We analyzed here, the immunoexpression of beta-1 integrin, p-cadherin, e- cadherin, and beta-catenin in hair follicles from 26 formalin-fixed and paraffin-embedded skin samples from human embryos and fetus between 12-23 weeks of gestational age. Results. The adhesion molecules beta-1 integrin and e-cadherin/p-cadherin were expressed from 12 weeks and seemed to play a role in regulating epidermis invagination. Beta-catenin immunostaining was negative in all cases; down regulation of this protein may be necessary for fetal hair development and thus facilitating hair follicle down growth. Discussion/Conclusion. Adhesion molecules are essential for hair follicle down growth and proliferation; integrins and cadherins play a major role in this process. More studies are needed to describe hair follicle developmentes
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.citationHistology and Histopathology Vol. 35, nº8 (2020)
dc.identifier.doihttps://doi.org/ 10.14670/HH-18-224
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/126189
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAdhesion moleculeses
dc.subjectHair folliclees
dc.subjectFetal developmentes
dc.subjectImmunohistochemistryes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleImmunoexpression of adhesion molecules during human fetal hair developmentes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.35, nº8 (2020)