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Role of mucosal immune response and histopathological study in European eel (Anguilla anguilla L.) intraperitoneal challenged by Vibrio anguillarum or Tenacibaculum soleae

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dc.contributor.authorConforto, Enmanuelle
dc.contributor.authorVilchez Gómez, Luciano
dc.contributor.authorParrinello, Daniela
dc.contributor.authorGiovanna,Parisi, María
dc.contributor.authorEsteban Abad, María de los Ángeles
dc.contributor.authorCammarata, Matteo
dc.contributor.authorGuardiola Abellán, Francisco Antonio
dc.contributor.departmentBiología Celular e Histología
dc.contributor.otherFacultad de Biología
dc.date.accessioned2026-01-29T08:13:10Z
dc.date.available2026-01-29T08:13:10Z
dc.date.copyright© 2021, Elsevier Ltd. All rights reserved.
dc.date.issued2021-05-18
dc.description.abstractThe external mucus layer that covers fish skin contains numerous immune substances scarcely studied that act as the first line of defence against a broad spectrum of pathogens. This study aimed to characterize and describe for the first time several humoral immune defence parameters in the skin mucus of the European eel (Anguilla anguilla) after intraperitoneal injection with Vibrio anguillarum or Tenacibaculum soleae. This study evaluated several immune-related enzymes and bactericidal activity against fish pathogenic bacteria in the skin mucus of European eels at 24, 48, and 72 h post-challenge. The results demonstrated that European eel skin mucus showed significant increments in peroxidase and lysozyme activity at 48 and 72 h after V. anguillarum challenge, compared to other experimental groups. In the case of antiprotease activity, an increase was observed at 24 h in the skin mucus of fish challenged with V. anguillarum compared to unchallenged fish, while this activity was undetected at 48 and 72 h. In contrast, protease activity had decreased at 48 and 72 h in the skin mucus of fish challenged with V. anguillarum compared to the unchallenged group. Regarding bactericidal activity, a high growth capacity of T. soleae was observed in the skin mucus of all experimental groups. Interestingly, the skin mucus from fish challenged with V. anguillarum exhibited increased bactericidal activity against this bacterium at 48 h, compared to unchallenged fish. Finally, severe histopathological alterations were observed in the gills and liver at the end of the trial (72 h), whereas the skin showed only an overspread presence of goblet cells in the challenged fish compared to unchallenged fish. The present results may give new insights into the mucosal immune system of this primitive species with potential applications in aquaculture.
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dc.format.extent10
dc.identifier.citationFish and Shellfish Immunology 114(2021)330–339
dc.identifier.doihttps://doi.org/10.1016/j.fsi.2021.05.011
dc.identifier.issn1050-4648
dc.identifier.urihttp://hdl.handle.net/10201/196269
dc.languageeng
dc.publisherElsevier
dc.relationThis work was partly supported by the MINECO co-funded by the European Regional Development Funds (ERDF/FEDER) (grant no. AGL2017-88370-C3-1-R) and Fundaci´ on S´eneca de la Regi´on de Murcia (Grupo de Excelencia, Grant no. 19883/GERM/15; Saavedra Fajardo program, Grant no. 20407/SF/17).
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S105046482100139X?via%3Dihub
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectBacterial challenge
dc.subjectSkin mucus
dc.subjectBactericidal activity
dc.subjectHistopathology
dc.subjectEuropean eel (Anguilla Anguilla L.)
dc.subjectMucosal immunity
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleRole of mucosal immune response and histopathological study in European eel (Anguilla anguilla L.) intraperitoneal challenged by Vibrio anguillarum or Tenacibaculum soleae
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
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relation.isAuthorOfPublicatione9f74fca-ae81-48b7-9b53-185f049b49ad
relation.isAuthorOfPublication73f1f7d1-c58a-4af9-b340-44afe7588147
relation.isAuthorOfPublication.latestForDiscoverye9f74fca-ae81-48b7-9b53-185f049b49ad
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