Publication: Lymph node hyalinization in elderly Japanese
Authors
Taniguchi, I. ; Murakami, G. ; Sato, A. ; Fujiwara, D. ; Ichikawa, H. ; Yajima, T. ; Kohama, G.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Lymph node hyalinization has been
comprehensively investigated using specimens obtained
from elderly Japanese and white Americans. Onion-peel
lesions and associated meshwork areas were often found
in the medullary sinus of the thoracic node (mediastinaltype
hyalinization), while eosinophilic, glassy and spotty
lesions were consistently seen in B lymphocyte areas of
the pelvic node (pelvic-type hyalinization). The
mediastinal-type hyalinization was comprised of thin
collagen fibrils (ca 50 nm in diameter), whereas the
pelvic-type hyalinization had thick fibrils (ca 150 nm in
diameter). This difference seemed to be consistent with a
difference in composite collagen fibrils of vascular walls
between the thoracic and pelvic regions. The pelvic-type
hyalinization was often or sometimes seen in other
nodes, such as cervical, axillary, abdominal and inguinal
nodes, especially in white Americans. The mediastinaltype
hyalinization, usually in combination with a sinus
filled with anthracotic macrophages, tended to be
observed in Japanese more frequently than in white
Americans. Anthracosis seemed to be connected to the
pathogenesis of the hyalinization. On the other hand,
because the lesion was weakly positive for Factor VIII
immunohistochemistry and because lesions were located
along thin vessels, the pelvic-type hyalinization seemed
to originate from vascular degeneration in the nodal
cortex. Due to the high incidence and large proportion in
total volume of the node, the hyalinization seems to be
one of the major events that diminish the nodal filtration
function and ruin the node with aging.
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