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Trained immunity induction by the inactivated mucosal vaccine MV130 protects against experimental viral respiratory infections

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dc.contributor.authorBrandi, Paola
dc.contributor.authorConejero, Laura
dc.contributor.authorCueto, Francisco J.
dc.contributor.authorMartínez Cano, Sarai
dc.contributor.authorDunphy, Gillian
dc.contributor.authorGómez, Manuel J.
dc.contributor.authorRelaño, Carlos
dc.contributor.authorSaz Leal, Paula
dc.contributor.authorEnamorado, Michel
dc.contributor.authorQuintas, Ana
dc.contributor.authorDopazo, Ana
dc.contributor.authorAmores Iniesta, Joaquín
dc.contributor.authorFresno, Carlos del
dc.contributor.authorNistal Villán, Estanislao
dc.contributor.authorArdavín, Carlos
dc.contributor.authorNieto, Antonio
dc.contributor.authorCasanovas, Miguel
dc.contributor.authorSubiza, José Luis
dc.contributor.authorSancho, David
dc.contributor.departmentSanidad Animal
dc.date.accessioned2024-10-18T06:46:42Z
dc.date.available2024-10-18T06:46:42Z
dc.date.issued2022-01-04
dc.description© 2021 The Authors. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Published version of a Published Work that appeared in final form in Cell Reports. To access the final edited and published work see https://doi.org/10.1016/j.celrep.2021.110184es
dc.description.abstractMV130 is an inactivated polybacterial mucosal vaccine that confers protection to patients against recurrent respiratory infections, including those of viral etiology. However, its mechanism of action remains poorly un-derstood. Here, we find that intranasal prophylaxis with MV130 modulates the lung immune landscape and provides long-term heterologous protection against viral respiratory infections in mice. Intranasal adminis-tration of MV130 provides protection against systemic candidiasis in wild-type and Rag1-deficient mice lacking functional lymphocytes, indicative of innate immune-mediated protection. Moreover, pharmacolog-ical inhibition of trained immunity with metformin abrogates the protection conferred by MV130 against influ-enza A virus respiratory infection. MV130 induces reprogramming of both mouse bone marrow progenitor cells and in vitro human monocytes, promoting an enhanced cytokine production that relies on a metabolic shift. Our results unveil that the mucosal administration of a fully inactivated bacterial vaccine provides pro-tection against viral infections by a mechanism associated with the induction of trained immunity.es
dc.formatapplication/pdfes
dc.format.extent20es
dc.identifier.doihttps://doi.org/10.1016/j.celrep.2021.110184
dc.identifier.eisbnCell Reports, 2022, Vol. 38 (11) : 110184es
dc.identifier.issnPrint: 2639-1856
dc.identifier.issnElectronic: 2211-1247
dc.identifier.urihttp://hdl.handle.net/10201/145422
dc.languageenges
dc.publisherCell Presses
dc.relationThis project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sk1odowska-Curie grant agreement No. 892965. Work in the D.S. laboratory is funded by the CNIC; by the European Research Council (ERC-2016-consolidator grant 725091); by the European Commission (635122-PROCROP H2020); by Ministerio de Ciencia e Innovacio´ n (MICINN), Agencia Estatal de Investigacio´ n (AEI), and Fondo Europeo de Desarrollo Regional (FEDER) (SAF2016-79040-R); by AEI (PID2019-108157RB); by Co-munidad de Madrid (B2017/BMD-3733 Immunothercan-CM); by FIS-Instituto de Salud Carlos III, MICINN and FEDER (RD16/0015/0018-REEM); by a collab-oration agreement with Inmunotek; by Atresmedia (Constantes y Vitales prize)es
dc.relation.publisherversionhttps://www.cell.com/cell-reports/fulltext/S2211-1247(21)01684-3es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPolybacterial immunomodulatores
dc.subjectMucosales
dc.subjectVaccinees
dc.subjectTrained immunityes
dc.subjectMacrophageses
dc.subjectCandida albicanses
dc.subjectViral infectiones
dc.subjectInfluenzaes
dc.subjectRespiratory infectiones
dc.subjectHuman monocyteses
dc.titleTrained immunity induction by the inactivated mucosal vaccine MV130 protects against experimental viral respiratory infectionses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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