Publication: Ultrastructural studies on
myofibrillogenesis and neogenesis of
skeletal muscles after prolonged traction in rabbits
Authors
Sun, J.S. ; Hou, S.M. ; Hang, Y. S. ; Liu, T,K. ; Lu, K.S.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Little is known about the morphological
response of muscle after long term traction. The purpose
of this study was to investigate the morphological
changes of skeletal muscle during limb lengthening.
After application of mini-extraskeletal fixator, the
hindlimb of New Zealand white rabbit was osteotomized
and then slowly lengthened at the rate of 1 mmlday up to
a 20 mm gain in length. The muscles of hindlimbs were
perfused and dissected. Morphological studies were
performed at electron microscopic level. Transmission
electron microscopy revealed foci of microtrauma at the
myotendinous junction. The distance between the
muscle fibers and tendon parenchyma increased, with
numerous primitive mesenchyme-like cells interposed
within this gap. The cytoplasmic space of these cells was
devoid of myofibril formation at the ends of stretched
fibers. Within the satellite near the myotendinous
junction myofilament production was observed in
various gradations of maturation. It is concluded that
myofibrillogenesis with traction neogenesis of skeletal
muscle during limb lengthening does exist and occurs
mainly near the myotendinous junction. The
myotendinous junction in mature skeletal muscle
actively participated in the process of limb lengthening.
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