Publication: Benign mast cell hyperplasia and atypical mast
cell infiltrates in penile lichen planus in adult men
Authors
Regauer, Sigrid ; Beham-Schmid, Christine
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Introduction. Lichen planus (LP) is a chronic
cytokine-mediated disease of possible auto-immune
etiology. 25% of men have anogenital manifestations.
Erosive penile LP causes a scarring phimosis of the
foreskin in uncircumcised men. Mast cells as potent
immune modulators have been implicated in a number of
autoimmune and chronic inflammatory diseases, but
have not been investigated in LP. Material and Methods.
Formalin-fixed tissues of 117 circumcision specimens of
adult men affected by LP were evaluated for the extent
of mast cell and lymphocyte infiltrates, characterized
immunohistochemically with antibodies to CD 3, 4, 8,
20, 21, 25, 30, 117c and human mast cell tryptase.
Specimens with dense mast cell infiltrates were analyzed
for point mutations of the c-kit gene (D816V). Results.
Unaffected skin and modified mucosa of foreskins
contained <5 mast cells/mm2. The inflammatory
infiltrate of LP-lesions displayed <15 mast cells/mm2 in
33/117 foreskins, 16-40 mast cells/mm2 in 22/117 and
>40 mast cells/mm2 (average 70, range 40-100) in
62/117 foreskins. Lesional mast cells of 29/117 (24%)
foreskins showed aberrant CD25-expression and/or
spindled morphology, with 11/29 men having erosive LP,
13/29 a lymphocytic vasculitis and 1/28 a systemic
mastocytosis. Neither CD30-expression nor c-kit
mutations were identified. Atypical mast cell infiltrates
in LP correlated with high disease activity, erosive LP
and presence of lymphocytic vasculitis. Conclusions.
Increased mast cells in penile LP, mostly representing a
benign hyperplasia / activation syndrome, suggests them
as targets for innovative therapy options for symptomatic
LP-patients not responding to corticosteroid therapy.
Presently, the biological implications of atypical mast
cell infiltrates in penile LP are unknown.
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Citation
Histology and Histopathology, vol. 29, nº 8, (2014)
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