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Tumor Necrosis Factor and Schistosoma mansoni egg antigen omega-1 shape distinct aspects of the early egg-induced granulomatous response

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dc.contributor.authorSchramm, Gabriele
dc.contributor.authorWilbers, Ruud H. P.
dc.contributor.authorIttiprasert, Wannaporn
dc.contributor.authorBrindley, Paul J.
dc.contributor.authorRinaldi, Gabriel
dc.contributor.authorBerriman, Matthew
dc.contributor.author Ramakrishnan, Lalita
dc.contributor.authorPagan, Antonio J.
dc.contributor.authorTakaki, Kevin K.
dc.contributor.authorRoca Soler, Francisco José
dc.contributor.departmentBioquímica y Biología Molecular B e Inmunología
dc.date.accessioned2026-02-25T16:01:14Z
dc.date.available2026-02-25T16:01:14Z
dc.date.copyright © 2021 Takaki et al.
dc.date.issued2021-01-19
dc.description.abstractInfections by schistosomes result in granulomatous lesions around parasite eggs entrapped within the host tissues. The host and parasite determinants of the Schistosoma mansoni egg-induced granulomatous response are areas of active investigation. Some studies in mice implicate Tumor Necrosis Factor (TNF) produced in response to the infection whereas others fail to find a role for it. In addition, in the mouse model, the S. mansoni secreted egg antigen omega-1 is found to induce granulomas but the underlying mechanism remains unknown. We have recently developed the zebrafish larva as a model to study macrophage recruitment and granuloma formation in response to Schistosoma mansoni eggs. Here we use this model to investigate the mechanisms by which TNF and omega-1 shape the early granulomatous response. We find that TNF, specifically signaling through TNF receptor 1, is not required for macrophage recruitment to the egg and granuloma initiation but does mediate granuloma enlargement. In contrast, omega-1 mediates initial macrophage recruitment, with this chemotactic activity being dependent on its RNase activity. Our findings further the understanding of the role of these host- and parasite-derived factors and show that they impact distinct facets of the granulomatous response to the schistosome egg.
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dc.format.extent12
dc.identifier.citationPLoS Negl. Trop Dis 15(1): e0008814.
dc.identifier.doihttps://doi.org/10.1371/journal.pntd.0008814
dc.identifier.eissn1935-2735
dc.identifier.issn1935-2727
dc.identifier.urihttp://hdl.handle.net/10201/213521
dc.languageeng
dc.publisherPublic Library of Science
dc.relationThis work was supported by Wellcome Trust core-funding support to the Wellcome Sanger Institute (award number 206194) (GR, MB) and NIH MERIT award (R37 AI054503) and a Wellcome Trust Principal Research Fellowship (LR). These studies were additionally supported by the Wellcome Trust Strategic Award number 107475/Z/15/Z, and the NIAID Schistosomiasis Resource Center for distribution through BEI Resources, NIH-NIAID Contract HHSN272201000005I (PJB, WI).
dc.relation.publisherversionhttps://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0008814
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.odsObjetivo 3: Salud
dc.titleTumor Necrosis Factor and Schistosoma mansoni egg antigen omega-1 shape distinct aspects of the early egg-induced granulomatous response
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
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relation.isAuthorOfPublication7f46a88a-1ff4-4f80-948e-7d636b80e75d
relation.isAuthorOfPublication.latestForDiscovery7f46a88a-1ff4-4f80-948e-7d636b80e75d
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