Publication: Microvascular changes in relation to inflammation and epidermal hyperplasia in chronic cutaneous lesions of psoriasis vulgaris
Authors
Výbohová, Desanka ; Adamicová, Katarína ; Mellová, Yvetta ; Hešková, Gabriela
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/HH-11-811
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info:eu-repo/semantics/article
Description
Abstract
Epidermal proliferation, inflammatory
changes and microvascular augmentation are prominent
features of chronic cutaneous psoriatic lesions. The
objective of this study was the investigation of blood and
lymphatic microvascular changes in relation to
epidermal changes and inflammatory infiltration in
dermis.
Immunohistochemical analysis with antibodies to
CD34, podoplanin, vascular endothelial growth factorsA and C (VEGF-A and C) and morphometric software
were used for quantification of the following parameters:
blood and lymphatic vessel area (BVA and LVA),
VEGF-A and VEGF-C positive area, inflammatory cell
infiltration in dermis (CIA) and epidermal area (EA).
In comparison to healthy skin psoriatic lesions
showed remarkable elevation of all measured parameters
with the following average increase: BVA (2.8-times
increased), LVA (2.6-times increased), VEGF-A and
VEGF-C area (in epidermis 29-times and 19-times
increased, in dermis 25-times and 15-times increased,
respectively ), and EA (3-times increased).
Statistical analysis revealed significant positive
correlation between CIA and EA in psoriatic samples.
Blood vessels area and VEGF-A expression in epidermis
showed mild positive correlation with epidermal
hyperplasia and weak positive correlation with dermal
inflammatory infiltration. VEGF-A expression in
epidermis also significantly correlated with blood
vessels area. As for the lymphatic microcirculation we
found a statistically significant positive correlation
between lymphatic vessels area and the cellular
infiltration in dermis but only weak correlation with
epidermal hyperplasia.
We hypothesize that angiogenesis in psoriasis is to a
greater extent responding to epidermal hyperplasia and
in a lesser way to inflammatory infiltration in dermis.
However, lymphangiogenesis is significantly related to
dermal inflammatory infiltration.
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Citation
Histology and Histopathology, Vol.32, nº5, (2017)
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