Publication: Diversity of mucins in labial glands of infants
Authors
Stoeckelhuber, Mechthild ; Kesting, Marco R. ; Loeffelbein, Denys J. ; Schmitz, Christoph ; Wolff, Klaus-Dietrich
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-213
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info:eu-repo/semantics/article
Description
Abstract
Mucins as highly glycosylated proteins
comprise multiple functions like protection,
homeostasis, immune defense, cell signaling. Various
epithelial tissues including glandular structures express
different specific mucin types. We investigated labial
salivary glands in infants for the occurrence of MUC1,
MUC2, MUC3, MUC4, MUC5AC, MUC5B, and
MUC7 by immunohistochemistry. MUC1 and MUC4
were detected in serous and ductal glandular cells,
partially intensified at the apical plasma membrane.
MUC3 was found in ductal glandular cells and in
myoepithelial cells. MUC5B exhibited a mosaic
expression pattern in mucous glandular endpieces.
MUC2 and MUC7 were abundant in serous acini.
Glandular structures were negative for MUC5AC. A
comprehensive study of specific mucins in labial
salivary glands of infants was presented for the first
time. As a representative of the minor salivary glands,
labial glands are, due to their localization, directly
exposed to environmental influences. The distribution of
a broad spectrum of mucins in infantile labial glands
indicates their importance early in human development
to sustain oral health.
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Citation
Histology and Histopathology Vol. 35, nº8 (2020)
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