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Sex‑dependent effects of forced exercise in the body composition of adolescent rats

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dc.contributor.authorKutsenko Shchegolska, Yevheniy
dc.contributor.authorBarreda, A.
dc.contributor.authorToval Sánchez, José Ángel
dc.contributor.authorGarrigos, D.
dc.contributor.authorMartínez Morga, Marta
dc.contributor.authorRibeiro do Couto, Bruno
dc.contributor.authorFerrán Bertone, José Luis
dc.contributor.departmentAnatomía Humana y Psicobiología
dc.contributor.otherFacultad de Medicina
dc.date.accessioned2026-01-13T12:38:40Z
dc.date.available2026-01-13T12:38:40Z
dc.date.copyright© 2021, The Author(s)
dc.date.issued2021-05-12
dc.description.abstractDetermining the body composition during adolescence can predict diseases such as obesity, diabetes, and metabolic syndromes later in life; and physical activity became an effective way to restore changes in body composition. However, current available literature assessing the body composition before, during and after adolescence in female and male rodents by in vivo techniques is scarce. Thus, by using computerized tomography, we aimed to define the baseline of the weight and body composition during the adolescence and young adulthood of female and male Sprague–Dawley rats (on P30, P60 and P90) under standard diet. Then, we determined the effect of 18 days of forced exercise on the body weight and composition during the early adolescence (P27-45). The highest percentual increments in weight, body volume and relative adipose contents occurred during the female and male adolescence. Forced running during the early adolescence decreased weight, body volume and relative adipose delta and increment values in males only. The adolescence of rats is a period of drastic body composition changes, where exercise interventions have sex-dependent effects. These results support a model that could open new research windows in the field of adolescent obesity.
dc.formatapplication/pdf
dc.format.extent15
dc.identifier.citationSci Rep 11, 10154 (2021)
dc.identifier.doihttps://doi.org/10.1038/s41598-021-89584-8
dc.identifier.eissn2045-2322
dc.identifier.urihttp://hdl.handle.net/10201/186211
dc.languageeng
dc.publisherNature Research
dc.relationThis study was funded by the Spanish Ministry of Science, Innovation and Universities (MCIU), State Research Agency (AEI) and European Regional Development Fund (FEDER); PGC2018-098229-B-100 to JLF) and by Séneca Foundation 19904/GERM/15).
dc.relation.publisherversionhttps://www.nature.com/articles/s41598-021-89584-8
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleSex‑dependent effects of forced exercise in the body composition of adolescent rats
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersión
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relation.isAuthorOfPublicationeb9f6a5b-a801-4042-b976-4780e73c0e87
relation.isAuthorOfPublicationd6a86d85-30c4-4b1f-98f9-935d7b99b71f
relation.isAuthorOfPublication.latestForDiscovery2d32b961-496c-412e-9c97-6d73a3c22ae9
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