Publication: Heart mitochondria in rats submitted to chronic hypoxia
Authors
Cervós-Navarro, J. ; Kunas, R.Ch. ; Sampaolo, S. ; Mansmann, U.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The effect of prolonged exposure to
normobaric hypoxia on the mitochondria of myocard of
rats exposed for several weeks to 8 and 7% O2 has been
morphometrically evaluated. Twelve male Wistar rats
housed in Nalgene cages (2 per cage) with a batch of six
cages placed in plexiglass chambers were maintained in
air/N2 mixtures containing different concentrations of
02. Six animals kept in similar cages under normoxia
served as controls. When at day 60 the FIOZ was
reduced to 8%, the weight increase stagnated and after
the 81st test day, on which the hypoxic animals were
subdivided into 8% and 7% groups the weight curve
showed a decrease in the mean body weight for both
groups. The arrest and the following loss of weight
beyond the 85th day may be interpreted as the
expression of a limit reached in the compensation
capacity. In the 8%-group the shape of the mitochondria
varied more markedly often with budding and furrowing
of the surface. In the 7%-group bizarre shapes and wide
variations in size with a decided shift towards larger
mitochondria were noteworthy. While rats kept under
8% oxygen exhibited a numerical increase in myocardial
mitochondria compared to controls, the mitochondria of
the 7%-group were numerically reduced. The results
suggest that hypoxia of 8% oxygen is compensatable, if
only to some extent, by an increasing surface of
mitochondrial membranes, and that further reduction of
oxygen causes compensation mechanisms to fail as seen
by the severe alterations of the mitochondrial population
of the cardiomyocyte in the 7%-group.
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