Publication: Role of myofibroblasts during normal tissue repair and excessive scarring:Interest of their assessment in nephropathies
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Date
2000
Authors
Badid, C. ; Mounier, N. ; Costa, A.M.A. ; Desmoulière, A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Following injury, tissue repair process takes
place involving inflammation, granulation tissue
formation and scar constitution. Granulation tissue
develops from the connective tissue surrounding the
damaged area and contains vessels, inflammatory cells,
fibroblasts and myofibroblasts. Myofibroblasts play an
important role in many tissue injuries and fibrocontractive
diseases. The process of normal wound
repair after tissue injury follows a closely regulated
sequence including the activation and the proliferation of
fibroblastic cells. In pathological situations, the normal
resolution stages are abrogated and the proliferation
of myofibroblasts continues, inducing excessive
accumulation of extracellular matrix. The differentiation
of fibroblastic cells into myofibroblasts is an early event
in the development of tissue fibrosis. Myofibroblastic
cells express smooth muscle cytoskeletal markers (asmooth
muscle actin in particular) and participate
actively in the production of extracellular matrix. The
evaluation of myofibroblast differentiation in renal
biopsies would be useful for histopathologists to
appreciate the intensity of tissue injury and particularly
to predict the long term outcome of some nephropathies.
Immunohistochemical studies for a-smooth muscle actin
should be made systematically in renal tissue biopsies.
Myofibroblastic differentiation appears to play a
significant role in the progression of renal failure and
seems to be a useful marker of progressive disease.
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